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田中 光 ＜たなか ひかる＞ 東邦大学薬学部教授、薬学博士
 最新-2020 | 2019-2010 | 2009-2000 | 1999-1990 | 1989-  最新-2015  最新-2015  最新-2006
 最新-2020 | 2019-2010 | 2009-2000 | 1999-1992 | 1991-  
原著論文 2009年－2000年
2009
| 154) |
Takahara A., Sasaki R., Nakamura M., Sendo
A., Sakurai Y., Namekata I., Tanaka H. Clobutinol delays ventricular
repolarization in the guinea-pig heart: comparison with cardiac effects
of hERG K+ channel inhibitor E-4031. J. Cardiovasc. Pharmacol. 54:
552-559 (2009) |
| 153) |
Namekata I., Tsuneoka Y., Takahara A.,
Shimada H., Sugimoto T., Takeda K., Nagaharu M., Shigenobu K., Kawanishi
T., Tanaka H. Involvement of the Na+/Ca2+ exchanger in the
automaticity of guinea-pig pulmonary vein myocardium as revealed by
SEA0400. J. Pharmacol. Sci. 110:111-116 (2009) |
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2008
| 152) |
Tanaka H., Komikado C., Namekata
I., Nakamura H., Suzuki M., Tsuneoka Y., Shigenobu K., Takahara A.
Species difference in the contribution of T-type calcium current to
cardiac pacemaking as revealed by R(-)-efonidipine. J. Pharmacol.
Sci. 1007:99-102 (2008) |
| 151) |
Iida-Tanaka N., Namekata I., Tamura M.,
Kawamata Y., Kawanishi T., Tanaka H. Membrane-labelled MDCK
cells and confocal microscopy for the analyses of cellular volume
and morphology. Biol. Pharmaceut. Bull. 34:731-734 (2008). |
| 150) |
Namekata I., Fujiki S., Kawakami Y., Moriwaki
R., Takeda K., Kawanishi T., Takahara A., Shigenobu K., Tanaka
H. Intracellular mechanisms and receptor types for endothelin-1-induced
positive and negative inotropy in mouse ventricular myocardium. Naunyn
Schmied Arch. Pharmacol. 376:386-395 (2008) |
| 149) |
Nouchi H., Takahara A., Nakamura H., Namekata
I., Sugimoto T., Tsuneoka Y., Takeda K., Tanaka T., Shigenobu K.,
Sugiyama A. Tanaka H. Chronic left atrial volume overload abbreviates
the action potential duration of the canine pulmonary vein myocardium
via activation of IK channel. Eur. J. Pharmacol. 597:81-85 (2008). |
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2007
| 148) |
Namekata I., Yamaguchi Y., Moriguchi S.,
Yamazaki S., Terasawa A., Yamagishi R., Aikawa T., Saito T., Kurashima
K., Seri K., Imamura Y., Akita H., Shigenobu K., Tanaka H.:
(R)-ACX, a pancreatic β-cell selective sulfonylurea, does
not aggravate myocardial ischemia-reperfusion damage. Eur. J. Pharmacol.
in press. |
| 147) |
Iida-Tanaka N., Namekata I., Kaneko M.,
Tamura M., Kawanishi T., Nakamura R., Shigenobu K., Tanaka H.:
Involvement of intracellular Ca2+ in the regulatory volume decrease
after hyposmotic swelling in MDCK cells. J. Pharmacol. Sci. 104:397-401
(2007) |
| 146) |
Nishimaru K., Fujiki S., Tanaka Y., Tanaka
H., Shigenobu K.: Endocardial endothelium-dependent positive inotropy
by Ca2+ pump inhibitors: possible involvement of store-operated Ca2+
entry. Pharmacology 80:200-206 (2007) |
| 145) |
Takahara A., Nakamura H., Nouchi H., Tamura
T., Tanaka T., Shimada H., Tamura M., Tsuruoka N., Takeda K., Tanaka
H., Shigenobu K., Hashimoto K., Sugiyama A.: Analysis of arrhythmogenic
profile in a canine model of chronic atrioventricular block by comparing
in vitro effects of the class III antiarrhythmic drug nifekalant on
the ventricular action potential indices between normal heart and
atrioventricular block heart. J. Pharmacol. Sci. 103:181-188 (2007) |
| 144) |
Tanaka H., Shimada H., Namekata
I., Kawanishi T., Iida-Tanaka N., Shigenobu K.: Involvement of the
Na+/Ca+ exchanger in ouabain-induced inotropy and arrhythmogenesis
in guinea-pig myocardium as revealed by SEA0400. J. Pharmacol. Sci.
103:241-246 (2007) |
| 143) |
Nouchi H., Kaeriyama S., Muramatsu A.,
Sato M., Hirose K., Shimizu N., Tanaka H., Shigenobu K.: Muscarinic
receptor subtypes mediating positive and negative inotropy in the
developing chick ventricle. J. Pharmacol. Sci.103:75-82 (2007) |
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2006
| 142) |
Kamata K., Satoh T., Matsumoto T., Noguchi
E., Taguchi K., Kobayashi T., Tanaka H., Shigenobu K.: Enhancement
of methoxamine-induced contractile responses of rat ventricle in streptozotocin-induced
diabetes is associated with a1Aadrenoceptor upregulation. Acta. Physiol.
Scand. 188:173-183 (2006) |
| 141) |
Matsuda T., Ito M., Ishimaru S., Tsuruoka
N., Saito T., Iida-Tanaka N., Hashimoto N., Yamashita T., Tsuruzoe
N., Tanaka H., Shigenobu K.: Blockade by NIP-142 of carbachol-induced
action potential shortening and GIRK 1/4 channel. J. Pharmacol. Sci.
101:303-310 (2006) |
| 140) |
Namekata I., Shimada H., Kawanishi T.,
Tanaka H., Shigenobu K.: Reduction by SEA0400 of myocardial
ischemia-induced cytoplasmic and mitochondrial Ca2+ overload. Eur.
J. Pharmacol. 533:108-115 (2006) |
| 139) |
Namekata I., Kawanishi T., Iida-Tanaka
N., Tanaka H., Shigenobu K.: Quantitative fluorescence measurement
of cardiac Na+/Ca2+ exchanger inhibition by kinetic analysis in stably
transfected HEK293 cells. J. Pharmacol. Sci. 101: 356-360 (2006) |
| 138) |
Kato K., Nouchi H., Ishikura K., Takaishi
S., Motodate S., Tanaka H., Okudaira K., Mochida T., Nishigaki
R., Shigenobu K., Akita H.: A facile access to spiro furanone skeleton
based on Pd(II)-mediated cyclization-carbonylation of progargylic
esters. Tetrahedron 62: 2545-2554 (2006) |
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2005
| 137) |
Otsuka K., Tanaka Y., Tanaka H.,
Koike K., Shigenobu K.: Comparison of the inhibitory effects of docosahexaenoic
acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig
aorta. Biol. Pharm. Bull. 28:1298-1300 (2005) |
| 136) |
Bai C., Namekata I., Kurokawa J., Tanaka
H., Shigenobu K., Furukawa T.: Role of nitric oxide in Ca2+ sensitivity
of the slowly activating delayed rectifier K+ current in cardiac myocytes.
Circ. Res. 96:64-72 (2005) |
135) |
Namekata I., Nakamura H., Tanaka H.,
Shigenobu K.: Cardioprotection without cardiosuppression by SEA0400,
a novel inhibitor of Na+-Ca2+ exchanger, during ischemia-reperfusion
injury in guinea-pig myocardium. Life Sci. 77:312-324 (2005) |
| 134) |
Kawai H., Suzuki T., Kobayashi T., Sakurai
H., Ohata H., Honda K., Momose K., Namekata I., Tanaka H.,
Shigenobu K., Hayakawa T., Kawanishi T.: Simultaneous real-time detection
of initiator- and effector-caspase activation by double FRET analysis.
J. Pharmacol. Sci. 97:361-368 (2005) |
| 133) |
Matsuda T., Takeda K., Ito M., Yamagishi
R., Tamura M., Nakamura H., Saito T., Itokawa M., Yamashita T., Tsuruzoe
N., Tanaka H., Shigenobu K.: Atria selective prolongation by
NIP-142 of refractory period and action potential duration in guinea-pig
myocardium. J. Pharmacol. Sci. 98:33-40 (2005) |
| 132) |
Tanaka H., Namekata I., Takeda
K., Shimizu Y., Moriwaki R., Hirayama W., Sato A., Kazama A., Kawanishi
T., Shigenobu K.: Unique excitation -contraction characteristics of
mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+
exchanger. Naunyn-Schmied. Arch. Pharmacol., 371:526-534 (2005) |
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2004
| 131) |
Namekata I., Yamagishi R., Kato Y., Nakamura
R., Tanaka H., Shigenobu K.: Propagation of normal and abnormal
cytoplasmic Ca2+ oscillation into the cell nucleus in cardiomyocytes.
Bioimages, 12:61-69 (2004) |
| 130) |
Tanaka H., Komikado C., Shimada
H., Takeda K., Namekata I., Kawanishi T., Shigenobu K.: The R (-)-enantiomer
of efonidipine blocks T-type but not L-type calcium current in guinea-pig
ventricular myocardium. J. Pharmacol. Sci. 96:499-501 (2004) |
| 129) |
Takeda K., Yamagishi R., Masumiya H.,
Tanaka H., Shigenobu K.: Effect of cilnidipine on L- and T-type
calcium currents in guinea-pig ventricle and action potential in rabbit
sinoatrial node. J. Pharmacol. Sci. 95: 398-401 (2004) |
| 128) |
Masumiya H., Saito M., Ito M., Matsuda
T., Noguchi K., Iida-Tanaka N., Tanaka H., Shigenobu K.: Lack
of action potential-prolonging effect of terfenadine on rabbit myocardial
preparations. Biol. Pharm. Bull. 27: 131-135 (2004) |
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2003
| 127) |
Masumiya H., Yamamoto H., Hemberger M.,
Tanaka H., Shigenobu K., Chen SRW., Furukawa T.: The mouse
sino-atrial node expersses both the type 2 and type 3 Ca release channels/ryanodine
receptors. FEBS Lett. 553: 141-144 (2003) |
| 126) |
Tanaka Y., Okamoto T., Imai T., Yamamoto
Y., Horinouchi T., Tanaka H., Koike K., Shigenobu K.: Bk(Ca)
channel activity enhances with muscle stretch in guinea-pig urinary
bladder smooth muscle. Res Commun Mol Pathol Pharmacol. 113-114: 247-252
(2003) |
| 125) |
Tanaka Y., Okamoto T, Imai T, Horinouchi
T, Tanaka H., Shigenobu K., Koike K.: Phospholipase C inhibitors
suppress spontaneous mechanical activity of guinea pig urinary bladder
smooth muscle. Biol. Pharm. Bull. 26:1192-1194. (2003) |
| 124) |
Nishimaru K., Tanaka Y., Tanaka H.,
Shigenobu K.: Inhibition of agonist-induced positive inotropy by a
selective Rho-asociated kinase inhibitor, Y-27632. J. Pharmacol. Sci.,
92: 424-427 (2003) |
| 123) |
Nishimaru K., Tanaka Y., Tanaka H.,
Shigenobu K.: Pharmacological evidence for involvement of phospholipase
D, protein kinase C and sodium-calcium exchanger in a-adrenoceptor-mediated
negative inotropy in adult mouse ventricle. J. Pharmacol. Sci. 92:196-202
(2003) |
| 122) |
Tanaka Y., Akutsu A., Tanaka H.,
Horinouchi T., Tsuru H., Koike K., Shigenobu K.: Pharmacological evidence
that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels
function as a negative feedback element for sympathetic neurotransmission
by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the
relaxation of rabbit facial vein. Naunyn Schmied. Arch. Pharmacol.
367:35-42 (2003) |
| 121) |
Tanaka H., Nishimaru K., Makuta
R., Hirayama W., Kawamura T., Matsuda T., Tanaka Y., Shigenobu K.:
Possible involvement of prostaglandins F2α and D2 in acetylcholine-induced
positive inotropy in isolated mouse left atria. Pharmacology, 67:
157-162 (2003) |
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2002
| 120) |
Tanaka Y., Horinouchi T., Tanaka H.,
Shigenobu K., Koike K.: BK channels play an important role as a negative
feedback mechanism in the regulation of spontaneous rhythmic contraction
of urinary bladder smooth muscles. Folia Pharmacol. Jpn. 120: 106P-108P
(2002) |
| 119) |
Otsuka K., Tanaka H., Horinouchi
T., Koike K., Shigenobu K., Tanaka Y.: Functional contribution of
voltage-dependent and Ca2+-activated K+ channels to the relaxation
of guinea-pig aorta in response to natriuretic peptides. J. Smooth
Muscle Res. 38: 117-129 (2002) |
| 118) |
Imai T., Tanaka Y., Okamoto T., Horinouchi
T., Tanaka H., Koike K., Shigenobu K.: 2-Aminoethoxydiphenyl
borate causes dissociation between membrane electrical and mechanical
activity in guinea-pig urinary bladder smooth muscle. Naunyn Schmeid.
Arch. Pharmacol. 366: 282-285 (2002) |
| 117) |
Imai T., Tanaka Y., Okamoto T., Yamamoto
Y., Horinouchi T., Tanaka H., Koike K., Shigenobu K.: Evidence
that action potential generation is not the exclusive determinant
to trigger spontaneous myogenic contraction of guinea-pig urinary
bladder smooth muscle. Acta Physiol. Scand. 176: 57-63 (2002) |
| 116) |
Noguchi K., Kase J., Saitoh M., Masumiya
H., Saitoh M., Nakazawa T., Tanaka Y., Tanaka H., Hashimoto
K., Shigenobu K.: Effects of HNS-32, a novel antiarrhythmic agent,
on guinea-pig myocardium. Pharmacology, 64:36-42 (2002) |
| 115) |
Tanaka Y., kamibayashi M., Yamashita Y.,
Imai T., Tanaka H., Ishii K., Shigenobu K.: Evidence for the
possible involvement of Ca2+ entry blockade in the relaxation by class
I antiarrhythmic drugs in the isolated pig coronary smooth muscle.
Naunyn Schmeid. Arch. Pharmacol. 365: 56-66 (2002) |
| 114) |
Tanaka Y, Horinouchi T, Tanaka H.,
Shigenobu K., Koike K.: BK channels play an important role as a negative
feedback mechanism in the regulation of spontaneous rhythic contraction
of urinary bladder smooth muscle. Fol. Pharmacol. Jpn. 120: 106P-108P
(2002) |
| 113) |
Tanaka H., Nishimaru K., Aikawa
T., Hirayama W., Tanaka Y., Shigenobu K.: Effect of SEA0400, a novel
inhibitor of myocardial sodium-calcium exchanger, on myocardial membrane
currents. Br. J. Pharmacol. 135: 1096-1100 (2002) |
| 112) |
Tanaka H., Ishii T., Fujisaki R.,
Miyamoto Y., Tanaka Y., Aikawa T., Hirayama W., Kawanishi T., Shigenobu
K.: Effect of manganese on guinea pig ventricle: initial depression
and late augmentation of contractile force. Biol. Pharm. Bull. 25:
323-326 (2002) |
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2001
| 111) |
Imai T., Okamoto T., Yamamoto Y., Tanaka
H., Koike K., Shigenobu K., Tanaka Y.: Effects of different types
of K channel modulators on the spontaneous myogenic contraction of
guinea-pig urinary bladder smooth muscle. Acta Physiol. Scand. 173:
323-333 (2001) |
| 110) |
Yamaki F., Kaga M., Horinouchi T., Tanaka
H., Koike K., Shigenobu K., Toro L., Tanaka Y.: Maxi K channel-mediated
relaxation of guinea-pig aorta following stimalation of IP receptor
with beraprost via cyclic AMP-dependent and independent mechanisms.
Naunyn Schmeid. Arch. Pharmacol. 364: 538-550 (2001) |
| 109) |
Tanaka H., Masumiya H., Sekine
T., Kawanishi T., Hayakawa T., Miyata S., Sato Y. Nakamura R., Shigenobu
K.: Involvement of Ca2+ waves in excitation contraction coupling of
rat atrial cardiomyocytes. Life Sci. 70: 715-726 (2001) |
| 108) |
Masumiya H., Kase J., Kawanishi T., Hayakawa
T., Miyata S., Sato R., Nakamura R., Tanaka H., Shigenobu K.:
Effect of T-type and L-type Ca2+ channel blockade on early phase Ca2+
transients in rat atrial and ventricular cardiomyocytes. Bioimages
9: 87-93 (2001) |
| 107) |
Ono K., Masumiya H., Sakamoto A., Christe
G., Shijuku T., Tanaka H., Shigenobu K., Ozaki Y.: Electrophysiological
analysis of the negative chronotropic effect of endothelin-1 in rabbit
SA node cells. J. Physiol. 537:467-488 (2001) |
| 106) |
Tanaka Y., Mitani A., Igarashi T., Someya
S., Otsuka K., Imai T., Yamaki F., Tanaka H., Saitoh M., Nakazawa
T., Noguchi K., Hashimoto K., Shigenobu K.: HNS-32, a novel azulene-1-carboxamidine
derivative, inhibits nifedipine-sensitive and -insensitive contraction
of the isolated rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol.
363:344-352 (2001). |
| 105) |
Tanaka H., Nishimaru K., Kobayashi
M., Matsuda T., Tanaka Y., Shigenobu K.: Acetylcholine-induced positive
inotropism mediated by prostaglandin released from endocardial endothelium
in mouse left atrium. Naunyn-Schmied. Arch. Pharmacol. 363: 577-582
(2001) |
| 104) |
Matsuda T., Masumiya H., Tanaka N., Tanaka
Y., Yamashita T., Tanaka H., Shigenobu K.: Inhibition of cloned
human cardiac Kv1.5 potassium channel current by a novel antiarrythmic
agent, NIP-142. Life Sci. 68: 2017-2024 (2001). |
| 103) |
Nishimaru K., Makuta R., Tanaka Y, Tanaka
H., Shigenobu K.: Pharmacological properties of excitation-contraction
mechanisms in isolated mouse left atria. Pharmacology 62: 87-91 (2001) |
| 102) |
Noguchi K., Ito C., Isobe Y., Fukushima
K., Tanaka Y., Tanaka H., Shigenobu K.: Effects of 5-HT4 receptor
agonist prokinetic agents on the action potential parameters of isolated
rabbit myocardium. Pharmacology 62: 73-79 (2001) |
| 101) |
Nishimaru K., Tanaka Y, Tanaka H.,
Shigenobu K.: a-adrenoceptor stimulation-mediated negative inotropism
and enhancement of Na+-Ca2+ exchange in mouse ventricle. Am. J. Physiol.
280: H132-H141 (2001) |
| 100) |
Tanaka Y. Kamibayashi M, Someya S, Yamaki F, Tanaka H, Shigenobu K. Potentiation by melatonin of 5-hydroxytryptamine-induced contraction in pig coronary artery. Res. Comm. Pharmacol. Toxicol. 6:47-57 (2001) |
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2000
| 99) |
Noguchi K., Saitoh M., Nakazawa T., Tanaka
H., Tanaka Y., Shigenobu K.: Cerebral artery selective inhibition
of protein kinase c-mediated contraction by HNS-32, a novel azulene-1-carboxamidine
derivative. Res. Commun. Mol. Pathol. Pharmacol. 107:45-54 (2000) |
| 98) |
Masumiya H., Kase J., Tanaka Y., Tanaka
H., Shigenobu K.: Frequency-dependent blockade of T-type Ca2+
current by efonidipine in cardiomyocytes. Life Sci. 68: 345-351 (2000) |
| 97) |
Tanaka Y., Someya S., Tanaka H.,
Tsuru H., Shigenobu K.: Potentiation of stretch-induced tone in the
rabbit facial vein by an isoquinoline derivative, LOE 908. Naunyn
Schmied. Arch. Pharmacol. 362:577-80 (2000) |
| 96) |
Tanaka Y., Igarashi T., Kaneko H., Yamaki
F., Mochizuki Y., Aida M., Taniguchi H., Tanaka H., Shigenobu
K.: NO-mediated MaxiKCa2+ channel activation produces relaxation of
guinea pig aorta independently of voltage-dependent L-type Ca2+ channels.
Gen Pharmacol. 34:159-65 (2000) |
| 95) |
Tanaka Y., Hayakawa S., Imai T., Akutsu
A., Hirano H., Tanaka H., Nakahara T., Ishii K., Shigenobu
K.: Possible involvement of endothelium-derived hyperpolarizing factor
(EDHF) in the depressor responses to platelet activating factor (PAF)
in rats. Br. J. Pharmacol. 131: 1113-1120 (2000) |
| 94) |
Tanaka Y., Kamibayashi M., Yamaki F.,
Saitoh M., Nakazawa T., Tanaka H., Noguchi K., Hashimoto K.,
Shigenobu K.: Relaxant action of azulene-1-carboxamidine derivative
N1, N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3,8-dimethylazulene-1-carboxamidine
(HNS-32) in pig coronary artery. Pharm. Pharmacol. Comm. 6: 397-404
(2000) |
| 93) |
Yamaki F., Tanaka H., Shigenobu
K., Tanaka Y.: Nitric oxide accounts for endothelium-dependent relaxation
of pig coronary artery in response to noradrenaline. Pharm. Pharmacol.
Commun. 6: 195-199 (2000) |
| 92) |
Tanaka Y., Imai T., Igarashi T., Takayanagi
K., Otsuka K., Yamaki F., Tanaka H., Shigenobu K.: Comparison
of the Ca2+ entry channels responsible for mechanical responses of
guinea-pig aorta to noradrenaline and thapsigargin using SK&F 96365
and LOE 908. Naunyn Schmied. Arch. Pharmacol. 362:160-168 (2000) |
| 91) |
Masumiya H., Tanaka Y., Tanaka H.,
Shigenobu K.: Inhibition of T-type and L-type Ca2+ currents by aranidipine,
a novel dihydropyridine Ca2+ antagonist. Pharmacology 61:57-61 (2000) |
| 90) |
Naito A., Ohtake Y., Hasegawa H., Fukaya
AY., Kurasawa T., Naito K., Matsukawa H., Oguma T., Ezure Y., Tsuriya
Y., Tanaka H., Koike K., Shigenobu K.: Pharmacological profile
of VP-343, a novel selective vasopressin V2 receptor antagonist in
rats. Biol. Pharm. Bull. 23:182-189 (2000) |
| 89) |
Nishimaru K., Tanaka Y, Tanaka H.,
Shigenobu K.: Positive and negative inotropic effects of muscarinic
receptor stimulation in mouse left atria. Life Sciences 66: 607-615
(2000) |
| 88) |
Masumiya H., Matsuda T., Tanaka Y., Tanaka
H., Shigenobu K.: Possible requirement of phosphonate moiety for
efonidipine effects on the sino-atrial node action potential. Life
Sciences 66: 239-244 (2000) |
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原著論文 最新-2020｜2019-2010｜2009-2000｜1999-1990｜1989- ｜もとのページ｜「心筋」トップ｜ページ先頭
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