東邦大学へ メディアネットセンターへ バーチャルラボラトリへ  
バーチャルラボラトリ 心筋−心臓は電気とカルシウムイオンで動いている!−
東邦大学 薬学部薬物学教室  
田中 光 行方 衣由紀 M口正悟
 | TOP | 心臓に関する基礎知識 | 心臓の電気現象 | 心臓の収縮 | 心筋の普遍性と多様性 | 循環系と血圧 |
 心臓の病気と治療薬 | エホニジピン物語 | プロフィ−ル | 免責事項 |

田中 光 <たなか ひかる> 東邦大学薬学部教授、薬学博士

最新-2020 | 2019-2010 | 2009-2000 | 1999-1990 | 1989-  最新-2015  最新-2015 最新-2006
最新-2020 | 2019-2010 | 2009-2000 | 1999-1992 | 1991-  

原著論文 2019年−2010年

2019
194) Yusuke Tanaka, Kae Obata, Tamano Ohmori, Kohei Ishiwata, Manato Abe, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka. Angiotensin Ⅱ induces automatic activity of the guinea pig pulmonary vein myocardium through activation of the IP3 receptor and the Na+-Ca2+-exchanger. Int. J. Mol. Sci. 20: 20: 1768 (2019)
193) Masahiko Irie, Haruhito Hiiro, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka. Involvement of the persistent Na+ current in the diastolic depolarization and automaticity of the guinea pig pulmonary vein myocardium. J. Pharmacol. Sci. 141: 9-16 (2019)
192) Naoki Agata, Yoshimitsu Kato, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka. Resistance of fetal guinea pig ventricular myocardium to hypoxia: maintained intracellular ATP prevents the opening of ATP-sensitive potassium channels. Biol. Pharm. Bull. 42: 268-272 (2019)
191) Iyuki Namekata, Yusuke Tanaka, Tamano Ohmori, Yayoi Tsuneoka, Shogo Hamaguchi, Hikaru Tanaka. Cell morphology and early phase Ca2+ transients of guinea pig pulmonary vein cardiomyocytes compared with atrial and ventricular cardiomyocytes. Bioimages. 37:1-12 (2019)
2018
190) Iyuki Namekata, Haruhito Hiiro, Haruna Kanae, Ayako Yoshino, Akihiro Kazama, Shogo Hamaguchi, Hikaru Tanaka. Acceleratory effect of ellagic acid on sarcoplasmic reticulum Ca2+ uptake and myocardial relaxation. Int. J. Hum. Cult. Stud. 28:701-707 (2018)
189) Xin Cao, Megumi Aimoto, Marie Fukumoto, Yoshimitsu Nagasawa, Hikaru Tanaka, Akira Takahara. Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria. J. Pharmacol. Sci. 136:73-78 (2018)
2017
188) Kanae H, Hamaguchi S, Wakasugi Y, Kusakabe T, Kato K, Namekata I, Tanaka H. Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium. J. Pharmacol. Sci. 135:131-133 (2017)
187) Irie M, Tsuneoka Y, Shimobayashi M, Hasegawa N, Tanaka Y, Mochizuki S, Ichige S, Hamaguchi S, Namekata I, Tanaka H. Involvement of alpha- and beta-adrenoceptors in the automaticity of the isolated guinea pig pulmonary vein myocardium. J. Pharmacol. Sci. 133:247-253 (2017)
186) Tsuneoka Y, Irie M, Tanaka Y, Sugimoto T, Kobayashi Y, Kusakabe T, Kato K, Hamaguchi S, Namekata I, Tanaka H. Permissive role of reduced inwardly-rectifying potassium current density in the automaticity of the guinea pig pulmonary vein myocardium. J. Pharmacol. Sci. 133:195-202 (2017)
185) Namekata I, Hamaguchi S, Kusakabe T, Kato K, Tanaka H. Fluorescent analysis of the mitochondrial effect of a plasmalemmal Na+/Ca2+ exchanger inhibitor, SEA0400, in permeabilized H9c2 cells. Biol. Pharm. Bull. 40:1551-1555 (2017)
184) Namekata I, Kanazawa A, Hamaguchi S, Tanaka H, Iida-Tanaka N. Fluorescence imaging-based analysis of the mitochondrial permeability transition pore opening in cardiomyocyte-derived H9c2 cells. Int. J. Hum. Cult. Stud. 27:14-19 (2017)
183) Jin H, Fujita T, Jin M, Kurotani R, Namekata I, Hamaguchi S, Hidaka Y, Cai W, Suita K, Ohnuki Y, Mototani Y, Shiozawa K, Prajapati R, Liang C, Umemura M, Yokoyama U, Sato M, Tanaka H, Okumura S, Ishikawa Y. Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway. J. Mol. Cell. Cardiol. 108:170-180 (2017)
2016
182) Hamaguchi S, Tsuneoka Y, Hikita K, Tanaka Y, Namekata I, Tanaka H. Enhancement of automaticity by mechanical stretch in the isolated guinea pig pulmonary vein myocardium. Biol. Pharm. Bull. 39:1216-1219 (2016)
181) Nakamura Y, Sasaki R, Cao X, Wada T, Hamaguchi S, Izumi-Nakaseko H, Ando K, Tanaka H, Takahara A, Sugiyama A. Intravenous anti-influenza drug oseltamivir will not induce torsade depointes: Evidences from proarrhythmia model and action-potential assay. J. Pharmacol. Sci. 131:72-75 (2016).
180) Namekata I, Kaeriyama S, Hamaguchi S, Iida-Tanaka N, Kawanishi T, Tanaka H. Mitochondrial membrane potential oscillations in isolated cardiomyocytes as revealed by fluorescence microscopy. Current Topics in Pharmacology. 20: 39-44 (2016)
2015
179) Hamaguchi S, Tsuneoka Y, Tanaka A, Irie M, Tsuruta M, Nakayama T, Namekata I, Nada M, Aimoto M, Takahara A, Tanaka H. Manifestation of automaticity in the pulmonary vein myocardium of rats with abdominal aorto-venocaval shunt. J. Pharmacol. Sci. 128:212-215 (2015)
178) Ikaga R, Namekata I, Kotiadis VN, Ogawa H, Duchen M, Tanaka H, Iida-Tanaka N. Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem. Biophys. Rep. 4:187-195 (2015)
177) Namekata I, Hamaguchi S, Tanaka H. Pharmacological discrimination of plasmalemmal and mitochondrial sodium-calcium exchanger in cardiomyocyte-derived H9c2 cells. Biol.Pharm. Bull. 38:147-150 (2015)
176) Hasegawa C, Ikaga R, Namekata I, Tanaka H, Iida-Tanaka N. The role of mitochondria on the formation of lipid droplets in adipocytes: Live cell imaging of mitochondria and lipid droplets. Int. J. Hum.Cult. Stud. 25:268-270 (2015)
2014
175) Hamaguchi S, Kaneko M, Hashimoto R, Tamura M, Namekata I, Tanaka H, Iida-Tanaka N. Analysis of cellular morphology by confocal microscopy and a membrane-intercalating fluorescent dye PKH67. Int. J. Hum.Cult. Stud. 2014 24:217-221
174) Tanaka H, Takahashi Y, Hamaguchi S, Iida-Tanaka N, Oka T, Nishio M, Ohtsuki A, Namekata I. Effect of terfenadine and pentamidine on the hERG channel and its intracellular trafficking: Combined analysis with automated voltage clamp and confocal microscopy. Biol. Pharm. Bull. 2014 37(11):1826-1830
173) Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari, H Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J. Clin. Invest. 2014 124(6):2785-2801
2013
172) Hamaguchi S., Kawakami Y., Honda Y., Nemoto K., Ayaka S., Namekata I., Tanaka H. Developmental changes in excitation-contraction mechanisms of the mouse ventricular myocardium as revealed by functional and confocal imaging analyses. J. Pharmacol. Sci. 123:167-175 (2013)
171) Namekata I., Hamaguchi S., Wakasugi Y., Ohara M., Hirota Y., Tanaka H., Y. Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia. Eur. J. Pharmacol. 706:48-55 (2013)
170) Kitahara K., Nakamura Y., Tsuneoka Y., Adachi-Akahane S., Tanaka H., Yamazaki H., Takahara A., Yamazaki J., Ikeda T., Sugiyama A. Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro. Cardiovas. Toxicol. 13:234-243 (2013)
169) Takahara A., Takeda K., Hagiwara M., Tanaka H. Electrophysiological effects of the antiarrhythmic drug bepridil on the guinea pig pulmonary vein myocardium. Biol. Pharm. Bull. 36:311-315 (2013)
168) Namekata I., Kaeriyama S., Ikaga R., Tanaka H., Iida-Tanaka N. Cellular flavoprotein fluorescence imaging for the analysis of mitochondrial function. Int. J. Hum. Cult. Stud. 23: 305-309 (2013)
2012
167) Takahara A., Fujiwara K., Ohtsuki A., Oka T., Namekata I., Tanaka H. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J. Pharmacol. Sci. 120:165-175 (2012)
166) Tsuneoka Y., Kobayashi Y., Honda Y., Namekata I., Tanaka H. Electrical activity of the mouse pulmonary vein myocardium. J. Pharmacol. Sci. 119:287-292 (2012)
165) Takahara A., Takeda K., Tsuneoka Y., Hagiwara M., Namekata I., Tanaka H. Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea pig pulmonary vein myocardium. J. Pharmacol. Sci. 118:506-511 (2012)
164) Asada Y., Li W., Terada T., Kuang X., Li Q., Takafumi Y., Hamaguchi S., Namekata I., Tanaka H., Koike K. Labdane-type diterpenoids from hairy root cultures of Coleus forskolii. Phytochemistry 79:141-146 (2012)
163) Yoshizawa A., Nagai S., Baba Y., Yamada T., Matsui M., Tanaka H., Miyoshi S., Amagai M., Yoshikawa T., Ogawa S., Koyosu S. Autoimmunity against M2 muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. Eur. J. Immunology 42:1152-1163 (2012)
2011
162) Nouchi H., Kiryu N., Kimata M., Tsuneoka Y., Hamaguchi S., Namekata I., Takahara A., Shigenobu K., Tanaka H. Developmental changes in action potential prolongation by K+-channel blockers in chick ventricle. J. Pharmacol. Sci. 115:235-238 (2011)
161) Takahara A, Sugimoto T, Kitamura T, Takeda K, Yayoi Tsuneoka, Namekata I, Tanaka H. Electrophysiological and pharmacological characteristics of triggered activity elicited in guinea-pig pulmonary vein myocardium. J. Pharmacol. Sci. 115:176-181 (2011)
160) Namekata I., Tsuruoka N., Tsuneoka Y., Matsuda T., Takahara A., Tanaka Y., Suzuki T., Takahashi T., Iida-Tanaka N., Tanaka H. Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. Biol. Pharm. Bull. 34: 153-155(2011)
2010
159) Namekata I., Tsuneoka Y., Akiba A., Nakamura H., Shimada H., Takahara A., Tanaka H. Intracellular calcium and membrane potential oscillations in the guinea-pig and rat pulmonary vein myocardium. Bioimages 18:11-22 (2010)
158) Yamashiro K., Sasano T., Tojo K., Namekata I., Kurokawa J., Sawada N., Suganami T., Kamei Y., Tanaka H., Tajima N., Utsunomiya K., Ogawa Y., Furukawa T. Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem Biophys Res Commun. 398:284-289 (2010)
157) Agata N., Kato Y., Namekata I., Takahara A., Tanaka H., Chino D., Koike K., Tanaka Y. H2 receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria. Biol. Pharm. Bull. 33:2033-2035 (2010)
156) Tanaka H., Namekata I., Ogawa T., Tsuneoka Y., Komikado C., Takahara A., Iida-Tanaka N., Izumi-Nakaseko H., Tsuru H., Adachi-Akahane S. Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits Cav1.2, Cav1.3 and Cav3.1. Eur J Pharmacol. 649:263-267 (2010)
155) Tanaka H., Namekata I., Hamaguchi S., Kawamura T., Masuda H., Tanaka Y., Iida-Tanaka N., Takahara A. Effect of NIP-142 on potassium channel α-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization. Biol. Pharm. Bull. 33: 138-141 (2010)

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