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バーチャルラボラトリ　心筋－心臓は電気とカルシウムイオンで動いている！－
東邦大学　薬学部薬物学教室　　
田中 光　行方 衣由紀　濵口正悟
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行方　衣由紀　＜なめかた　いゆき＞　東邦大学薬学部准教授、薬学博士

最新-2010｜2009-2004　 最新-2007　 最新-2010　 最新-2004　 最新-2010｜2009-2003　 最新-2006　

原著英語論文　2009年-2004年

2009年
17) Akira Takahara, Rieko Sasaki, Mariko Nakamura, Akiko Sendo, Yukiko Sakurai, Iyuki Namekata, Hikaru Tanaka. Clobutinol delays ventricular repolarization in the guinea-pig heart: comparison with cardiac effects of hERG K+ channel inhibitor E-4031. J. Cardiovasc. Pharmacol. 54(6): 552-559. 2009
16) Iyuki Namekata, Yayoi Tsuneoka, Akira Takahara, Hideaki Shimada, Takahiko Sugimoto, Kiyoshi Takeda, Midori Nagaharu, Koki Shigenobu, Toru Kawanishi, Hikaru Tanaka. Involvement of the Na+/Ca2+ exchanger in the automaticity of guinea-pig pulmonary vein myocardium as revealed by SEA0400. J. Pharmacol. Sci. 110(1): 111-116. 2009
2008年
15) Hideaki Nouchi, Akira Takahara, Hideki Nakamura, Iyuki Namekata, Takahiko Sugimoto, Yayoi Tsuneoka, Kiyoshi Takeda, Toshikazu Tanaka, Koki Shigenobu, Atsushi Sugiyama, Hikaru Tanaka. Chronic left atrial volume overload abbreviates the action potential duration of the canine pulmonary vein myocardium via activation of IK channel. Eur. J. Pharmacol. 597(1-3):81-85. 2008.
14) Hikaru Tanaka, Chisa Komikado, Iyuki Namekata, Hideki Nakamura, Mariko Suzuki, Yayoi Tsuneoka, Koki Shigenobu, Akira Takahara. Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by R(-)-efonidipine. J. Pharmacol. Sci. 107(1):99-102. 2008
13) Naoko Iida-Tanaka, Iyuki Namekata, Miku Tamura, Yuko Kawamata, Toru Kawanishi, Hikaru Tanaka. Membrane-labelled MDCK cells and confocal microscopy for the analyses of cellular volume and morphology. Biol Pharm Bull. Vol. 34(4):731-734. 2008
12) Iyuki Namekata, Shinpei Fujiki, Yuko Kawakami, Rina Moriwaki, Kentaro Takeda, Toru Kawanishi, Akira Takahara, Koki Shigenobu, Hikaru Tanaka. Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium. Naunyn-Schmied. Arch. Pharmacol. 376(6):385-395. 2008
2007年
11) Iyuki Namekata, Yusuke Yamaguchi, Shuhei Moriguchi, Satoshi Yamazaki, Akihiko Terasawa, Reiko Yamagishi, Tokiko Aikawa, Tomoaki Saito, Katsumi Kurashima, Kenji Seri, Yorishige Imamura, Hiroyuki Akita, Koki Shigenobu, Hikaru Tanaka. (R)-ACX, a -cell selective sulfonylurea, does not aggravate cardiac ischemia-reperfusion damage. Eur. J. Pharmacol. 577(1-3): 211-218. 2007.
10) Naoko Iida-Tanaka, Iyuki Namekata, Megumi Kaneko, Miku Tamura, Toru Kawanishi, Ryu Nakamura, Hikaru Tanaka, Koki Shigenobu. Involvement of intracellular Ca2+ in the regulatory volume decrease after hyposmotic swelling in MDCK cells. J. Pharmacol. Sci. 104(4): 397-401. 2007.
9) Hikaru Tanaka, Hideaki Shimada, Iyuki Namekata, Toru Kawanishi, Koki Shigenobu. Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400. J. Pharmacol. Sci. 103(2): 241-246. 2007
2006年
8) Iyuki Namekata, Toru Kawanishi, Naoko Iida-Tanaka, Hikaru Tanaka, Koki Shigenobu. Quantitative fluorescence measurement of cardiac Na+/Ca2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells. J. Pharmacol. Sci. 101(4): 356-60. 2006.
7) Iyuki Namekata, Hideaki Shimada, Toru Kawanishi, Hikaru Tanaka, Koki Shigenobu. Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload. Eur. J. Pharmacol. 543(1-3): 108-115. 2006.
2005年
6) Chang-Xi Bai, Iyuki Namekata, Junko Kurokawa, Hikaru Tanaka, Koki Shigenobu, Tetsushi Furukawa. Role of nitric oxide in Ca2+ -sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes. Circ. Res. 96(1): 64-72. 2005.
5) Hiroshi Kawai, Takuo Suzuki, Tetsu Kobayashi, Haruna Sakurai, Hisayuki Ohata, Kazuo Honda, Kazutaka Momose, Iyuki Namekata, Hikaru Tanaka, Koki Shigenobu, Ryu Nakamura, Takao Hayakawa, Toru Kawanishi. Simultaneous real-time detection of initiator- and effecter-caspase activation by double FRET analysis. J. Pharmacol. Sci. 97(3): 361-368. 2005.
4) Hikaru Tanaka, Iyuki Namekata, Kentaro Takeda, Akihiro Kazama,Yoshiko Shimizu, Rina Moriwaki, Wataru Hirayama, Akira Sato, Toru Kawanishi, Koki Shigenobu. Unique excitation-contracion characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger. Naunyn-Schmied. Arch. Pharmacol. 371(6): 526-34. 2005.
3) Iyuki Namekata, Hideki Nakamura, Hideaki Shimada, Hikaru Tanaka, Koki Shigenobu. Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium. Life Sci. 77(3): 312-324. 2005.
2004年
2) Hikaru Tanaka, Chisa Komikado, Hideaki Shimada, Kentaro Takeda, Iyuki Namekata, Toru Kawanishi, Koki Shigenobu. The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea-pig ventricular myocardium. J. Pharmacol. Sci. 96(4): 499-501. 2004.
1) Iyuki Namekata, Reiko Yamagishi, Yoshimitsu Kato, Ryu Nakamura , Hikaru Tanaka, Koki Shigenobu. Propagation of normal and abnormal cytoplasmic Ca2+ oscillations into the cell nucleus in cardiomyocytes. Bioimages Vol.12(2-4): 61-69. 2004.

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