東邦大学へ メディアネットセンターへ バーチャルラボラトリへ  
バーチャルラボラトリ 心筋−心臓は電気とカルシウムイオンで動いている!−
東邦大学 薬学部薬物学教室  
田中 光 行方 衣由紀 M口正悟
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田中 光 <たなか ひかる> 東邦大学薬学部教授、薬学博士

原著論文 2009年−2000年

2009
153) Takahara A., Sasaki R., Nakamura M., Sendo A., Sakurai Y., Namekata I., Tanaka H. Clobutinol delays ventricular repolarization in the guinea-pig heart: comparison with cardiac effects of hERG K+ channel inhibitor E-4031. J. Cardiovasc. Pharmacol. 54: 552-559 (2009)
152) Namekata I., Tsuneoka Y., Takahara A., Shimada H., Sugimoto T., Takeda K., Nagaharu M., Shigenobu K., Kawanishi T., Tanaka H. Involvement of the Na+/Ca2+ exchanger in the automaticity of guinea-pig pulmonary vein myocardium as revealed by SEA0400. J. Pharmacol. Sci. 110:111-116 (2009)

2008
151) Tanaka H., Komikado C., Namekata I., Nakamura H., Suzuki M., Tsuneoka Y., Shigenobu K., Takahara A. Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by R(-)-efonidipine. J. Pharmacol. Sci. 1007:99-102 (2008)
150) Iida-Tanaka N., Namekata I., Tamura M., Kawamata Y., Kawanishi T., Tanaka H. Membrane-labelled MDCK cells and confocal microscopy for the analyses of cellular volume and morphology. Biol. Pharmaceut. Bull. 34:731-734 (2008).
149) Namekata I., Fujiki S., Kawakami Y., Moriwaki R., Takeda K., Kawanishi T., Takahara A., Shigenobu K., Tanaka H. Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium. Naunyn Schmied Arch. Pharmacol. 376:386-395 (2008)
148) Nouchi H., Takahara A., Nakamura H., Namekata I., Sugimoto T., Tsuneoka Y., Takeda K., Tanaka T., Shigenobu K., Sugiyama A. Tanaka H. Chronic left atrial volume overload abbreviates the action potential duration of the canine pulmonary vein myocardium via activation of IK channel. Eur. J. Pharmacol. 597:81-85 (2008).

2007
147) Namekata I., Yamaguchi Y., Moriguchi S., Yamazaki S., Terasawa A., Yamagishi R., Aikawa T., Saito T., Kurashima K., Seri K., Imamura Y., Akita H., Shigenobu K., Tanaka H.: (R)-ACX, a pancreatic β-cell selective sulfonylurea, does not aggravate myocardial ischemia-reperfusion damage. Eur. J. Pharmacol. in press.
146) Iida-Tanaka N., Namekata I., Kaneko M., Tamura M., Kawanishi T., Nakamura R., Shigenobu K., Tanaka H.: Involvement of intracellular Ca2+ in the regulatory volume decrease after hyposmotic swelling in MDCK cells. J. Pharmacol. Sci. 104:397-401 (2007)
145) Nishimaru K., Fujiki S., Tanaka Y., Tanaka H., Shigenobu K.: Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors: possible involvement of store-operated Ca2+ entry. Pharmacology 80:200-206 (2007)
144) Takahara A., Nakamura H., Nouchi H., Tamura T., Tanaka T., Shimada H., Tamura M., Tsuruoka N., Takeda K., Tanaka H., Shigenobu K., Hashimoto K., Sugiyama A.: Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventricular block heart. J. Pharmacol. Sci. 103:181-188 (2007)
143) Tanaka H., Shimada H., Namekata I., Kawanishi T., Iida-Tanaka N., Shigenobu K.: Involvement of the Na+/Ca+ exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400. J. Pharmacol. Sci. 103:241-246 (2007)
142) Nouchi H., Kaeriyama S., Muramatsu A., Sato M., Hirose K., Shimizu N., Tanaka H., Shigenobu K.: Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle. J. Pharmacol. Sci.103:75-82 (2007)

2006
141) Kamata K., Satoh T., Matsumoto T., Noguchi E., Taguchi K., Kobayashi T., Tanaka H., Shigenobu K.: Enhancement of methoxamine-induced contractile responses of rat ventricle in streptozotocin-induced diabetes is associated with a1Aadrenoceptor upregulation. Acta. Physiol. Scand. 188:173-183 (2006)
140) Matsuda T., Ito M., Ishimaru S., Tsuruoka N., Saito T., Iida-Tanaka N., Hashimoto N., Yamashita T., Tsuruzoe N., Tanaka H., Shigenobu K.: Blockade by NIP-142 of carbachol-induced action potential shortening and GIRK 1/4 channel. J. Pharmacol. Sci. 101:303-310 (2006)
139) Namekata I., Shimada H., Kawanishi T., Tanaka H., Shigenobu K.: Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload. Eur. J. Pharmacol. 533:108-115 (2006)
138) Namekata I., Kawanishi T., Iida-Tanaka N., Tanaka H., Shigenobu K.: Quantitative fluorescence measurement of cardiac Na+/Ca2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells. J. Pharmacol. Sci. 101: 356-360 (2006)
137) Kato K., Nouchi H., Ishikura K., Takaishi S., Motodate S., Tanaka H., Okudaira K., Mochida T., Nishigaki R., Shigenobu K., Akita H.: A facile access to spiro furanone skeleton based on Pd(II)-mediated cyclization-carbonylation of progargylic esters. Tetrahedron 62: 2545-2554 (2006)

2005
136) Otsuka K., Tanaka Y., Tanaka H., Koike K., Shigenobu K.: Comparison of the inhibitory effects of docosahexaenoic acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig aorta. Biol. Pharm. Bull. 28:1298-1300 (2005)
135) Bai C., Namekata I., Kurokawa J., Tanaka H., Shigenobu K., Furukawa T.: Role of nitric oxide in Ca2+ sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes. Circ. Res. 96:64-72 (2005)
134) Namekata I., Nakamura H., Tanaka H., Shigenobu K.: Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia-reperfusion injury in guinea-pig myocardium. Life Sci. 77:312-324 (2005)
133) Kawai H., Suzuki T., Kobayashi T., Sakurai H., Ohata H., Honda K., Momose K., Namekata I., Tanaka H., Shigenobu K., Hayakawa T., Kawanishi T.: Simultaneous real-time detection of initiator- and effector-caspase activation by double FRET analysis. J. Pharmacol. Sci. 97:361-368 (2005)
132) Matsuda T., Takeda K., Ito M., Yamagishi R., Tamura M., Nakamura H., Saito T., Itokawa M., Yamashita T., Tsuruzoe N., Tanaka H., Shigenobu K.: Atria selective prolongation by NIP-142 of refractory period and action potential duration in guinea-pig myocardium. J. Pharmacol. Sci. 98:33-40 (2005)
131) Tanaka H., Namekata I., Takeda K., Shimizu Y., Moriwaki R., Hirayama W., Sato A., Kazama A., Kawanishi T., Shigenobu K.: Unique excitation -contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger. Naunyn-Schmied. Arch. Pharmacol., 371:526-534 (2005)

2004
130) Namekata I., Yamagishi R., Kato Y., Nakamura R., Tanaka H., Shigenobu K.: Propagation of normal and abnormal cytoplasmic Ca2+ oscillation into the cell nucleus in cardiomyocytes. Bioimages, 12:61-69 (2004)
129) Tanaka H., Komikado C., Shimada H., Takeda K., Namekata I., Kawanishi T., Shigenobu K.: The R (-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea-pig ventricular myocardium. J. Pharmacol. Sci. 96:499-501 (2004)
128) Takeda K., Yamagishi R., Masumiya H., Tanaka H., Shigenobu K.: Effect of cilnidipine on L- and T-type calcium currents in guinea-pig ventricle and action potential in rabbit sinoatrial node. J. Pharmacol. Sci. 95: 398-401 (2004)
127) Masumiya H., Saito M., Ito M., Matsuda T., Noguchi K., Iida-Tanaka N., Tanaka H., Shigenobu K.: Lack of action potential-prolonging effect of terfenadine on rabbit myocardial preparations. Biol. Pharm. Bull. 27: 131-135 (2004)

2003
126) Masumiya H., Yamamoto H., Hemberger M., Tanaka H., Shigenobu K., Chen SRW., Furukawa T.: The mouse sino-atrial node expersses both the type 2 and type 3 Ca release channels/ryanodine receptors. FEBS Lett. 553: 141-144 (2003)
125) Tanaka Y., Okamoto T., Imai T., Yamamoto Y., Horinouchi T., Tanaka H., Koike K., Shigenobu K.: Bk(Ca) channel activity enhances with muscle stretch in guinea-pig urinary bladder smooth muscle. Res Commun Mol Pathol Pharmacol. 113-114: 247-252 (2003)
124) Tanaka Y., Okamoto T, Imai T, Horinouchi T, Tanaka H., Shigenobu K., Koike K.: Phospholipase C inhibitors suppress spontaneous mechanical activity of guinea pig urinary bladder smooth muscle. Biol. Pharm. Bull. 26:1192-1194. (2003)
123) Nishimaru K., Tanaka Y., Tanaka H., Shigenobu K.: Inhibition of agonist-induced positive inotropy by a selective Rho-asociated kinase inhibitor, Y-27632. J. Pharmacol. Sci., 92: 424-427 (2003)
122) Nishimaru K., Tanaka Y., Tanaka H., Shigenobu K.: Pharmacological evidence for involvement of phospholipase D, protein kinase C and sodium-calcium exchanger in a-adrenoceptor-mediated negative inotropy in adult mouse ventricle. J. Pharmacol. Sci. 92:196-202 (2003)
121) Tanaka Y., Akutsu A., Tanaka H., Horinouchi T., Tsuru H., Koike K., Shigenobu K.: Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing omega-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of rabbit facial vein. Naunyn Schmied. Arch. Pharmacol. 367:35-42 (2003)
120) Tanaka H., Nishimaru K., Makuta R., Hirayama W., Kawamura T., Matsuda T., Tanaka Y., Shigenobu K.: Possible involvement of prostaglandins F2α and D2 in acetylcholine-induced positive inotropy in isolated mouse left atria. Pharmacology, 67: 157-162 (2003)

2002
119) Tanaka Y., Horinouchi T., Tanaka H., Shigenobu K., Koike K.: BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles. Folia Pharmacol. Jpn. 120: 106P-108P (2002)
118) Otsuka K., Tanaka H., Horinouchi T., Koike K., Shigenobu K., Tanaka Y.: Functional contribution of voltage-dependent and Ca2+-activated K+ channels to the relaxation of guinea-pig aorta in response to natriuretic peptides. J. Smooth Muscle Res. 38: 117-129 (2002)
117) Imai T., Tanaka Y., Okamoto T., Horinouchi T., Tanaka H., Koike K., Shigenobu K.: 2-Aminoethoxydiphenyl borate causes dissociation between membrane electrical and mechanical activity in guinea-pig urinary bladder smooth muscle. Naunyn Schmeid. Arch. Pharmacol. 366: 282-285 (2002)
116) Imai T., Tanaka Y., Okamoto T., Yamamoto Y., Horinouchi T., Tanaka H., Koike K., Shigenobu K.: Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol. Scand. 176: 57-63 (2002)
115) Noguchi K., Kase J., Saitoh M., Masumiya H., Saitoh M., Nakazawa T., Tanaka Y., Tanaka H., Hashimoto K., Shigenobu K.: Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium. Pharmacology, 64:36-42 (2002)
114) Tanaka Y., kamibayashi M., Yamashita Y., Imai T., Tanaka H., Ishii K., Shigenobu K.: Evidence for the possible involvement of Ca2+ entry blockade in the relaxation by class I antiarrhythmic drugs in the isolated pig coronary smooth muscle. Naunyn Schmeid. Arch. Pharmacol. 365: 56-66 (2002)
113) Tanaka Y, Horinouchi T, Tanaka H., Shigenobu K., Koike K.: BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythic contraction of urinary bladder smooth muscle. Fol. Pharmacol. Jpn. 120: 106P-108P (2002)
112) Tanaka H., Nishimaru K., Aikawa T., Hirayama W., Tanaka Y., Shigenobu K.: Effect of SEA0400, a novel inhibitor of myocardial sodium-calcium exchanger, on myocardial membrane currents. Br. J. Pharmacol. 135: 1096-1100 (2002)
111) Tanaka H., Ishii T., Fujisaki R., Miyamoto Y., Tanaka Y., Aikawa T., Hirayama W., Kawanishi T., Shigenobu K.: Effect of manganese on guinea pig ventricle: initial depression and late augmentation of contractile force. Biol. Pharm. Bull. 25: 323-326 (2002)

2001
110) Imai T., Okamoto T., Yamamoto Y., Tanaka H., Koike K., Shigenobu K., Tanaka Y.: Effects of different types of K channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol. Scand. 173: 323-333 (2001)
109) Yamaki F., Kaga M., Horinouchi T., Tanaka H., Koike K., Shigenobu K., Toro L., Tanaka Y.: Maxi K channel-mediated relaxation of guinea-pig aorta following stimalation of IP receptor with beraprost via cyclic AMP-dependent and independent mechanisms. Naunyn Schmeid. Arch. Pharmacol. 364: 538-550 (2001)
108) Tanaka H., Masumiya H., Sekine T., Kawanishi T., Hayakawa T., Miyata S., Sato Y. Nakamura R., Shigenobu K.: Involvement of Ca2+ waves in excitation contraction coupling of rat atrial cardiomyocytes. Life Sci. 70: 715-726 (2001)
107) Masumiya H., Kase J., Kawanishi T., Hayakawa T., Miyata S., Sato R., Nakamura R., Tanaka H., Shigenobu K.: Effect of T-type and L-type Ca2+ channel blockade on early phase Ca2+ transients in rat atrial and ventricular cardiomyocytes. Bioimages 9: 87-93 (2001)
106) Ono K., Masumiya H., Sakamoto A., Christe G., Shijuku T., Tanaka H., Shigenobu K., Ozaki Y.: Electrophysiological analysis of the negative chronotropic effect of endothelin-1 in rabbit SA node cells. J. Physiol. 537:467-488 (2001)
105) Tanaka Y., Mitani A., Igarashi T., Someya S., Otsuka K., Imai T., Yamaki F., Tanaka H., Saitoh M., Nakazawa T., Noguchi K., Hashimoto K., Shigenobu K.: HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 363:344-352 (2001).
104) Tanaka H., Nishimaru K., Kobayashi M., Matsuda T., Tanaka Y., Shigenobu K.: Acetylcholine-induced positive inotropism mediated by prostaglandin released from endocardial endothelium in mouse left atrium. Naunyn-Schmied. Arch. Pharmacol. 363: 577-582 (2001)
103) Matsuda T., Masumiya H., Tanaka N., Tanaka Y., Yamashita T., Tanaka H., Shigenobu K.: Inhibition of cloned human cardiac Kv1.5 potassium channel current by a novel antiarrythmic agent, NIP-142. Life Sci. 68: 2017-2024 (2001).
102) Nishimaru K., Makuta R., Tanaka Y, Tanaka H., Shigenobu K.: Pharmacological properties of excitation-contraction mechanisms in isolated mouse left atria. Pharmacology 62: 87-91 (2001)
101) Noguchi K., Ito C., Isobe Y., Fukushima K., Tanaka Y., Tanaka H., Shigenobu K.: Effects of 5-HT4 receptor agonist prokinetic agents on the action potential parameters of isolated rabbit myocardium. Pharmacology 62: 73-79 (2001)
100) Nishimaru K., Tanaka Y, Tanaka H., Shigenobu K.: a-adrenoceptor stimulation-mediated negative inotropism and enhancement of Na+-Ca2+ exchange in mouse ventricle. Am. J. Physiol. 280: H132-H141 (2001)

2000
99) Noguchi K., Saitoh M., Nakazawa T., Tanaka H., Tanaka Y., Shigenobu K.: Cerebral artery selective inhibition of protein kinase c-mediated contraction by HNS-32, a novel azulene-1-carboxamidine derivative. Res. Commun. Mol. Pathol. Pharmacol. 107:45-54 (2000)
98) Masumiya H., Kase J., Tanaka Y., Tanaka H., Shigenobu K.: Frequency-dependent blockade of T-type Ca2+ current by efonidipine in cardiomyocytes. Life Sci. 68: 345-351 (2000)
97) Tanaka Y., Someya S., Tanaka H., Tsuru H., Shigenobu K.: Potentiation of stretch-induced tone in the rabbit facial vein by an isoquinoline derivative, LOE 908. Naunyn Schmied. Arch. Pharmacol. 362:577-80 (2000)
96) Tanaka Y., Igarashi T., Kaneko H., Yamaki F., Mochizuki Y., Aida M., Taniguchi H., Tanaka H., Shigenobu K.: NO-mediated MaxiKCa2+ channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca2+ channels. Gen Pharmacol. 34:159-65 (2000)
95) Tanaka Y., Hayakawa S., Imai T., Akutsu A., Hirano H., Tanaka H., Nakahara T., Ishii K., Shigenobu K.: Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. Br. J. Pharmacol. 131: 1113-1120 (2000)
94) Tanaka Y., Kamibayashi M., Yamaki F., Saitoh M., Nakazawa T., Tanaka H., Noguchi K., Hashimoto K., Shigenobu K.: Relaxant action of azulene-1-carboxamidine derivative N1, N1-dimethyl-N2-(2-pyridylmethyl)-5-isopropyl-3,8-dimethylazulene-1-carboxamidine (HNS-32) in pig coronary artery. Pharm. Pharmacol. Comm. 6: 397-404 (2000)
93) Yamaki F., Tanaka H., Shigenobu K., Tanaka Y.: Nitric oxide accounts for endothelium-dependent relaxation of pig coronary artery in response to noradrenaline. Pharm. Pharmacol. Commun. 6: 195-199 (2000)
92) Tanaka Y., Imai T., Igarashi T., Takayanagi K., Otsuka K., Yamaki F., Tanaka H., Shigenobu K.: Comparison of the Ca2+ entry channels responsible for mechanical responses of guinea-pig aorta to noradrenaline and thapsigargin using SK&F 96365 and LOE 908. Naunyn Schmied. Arch. Pharmacol. 362:160-168 (2000)
91) Masumiya H., Tanaka Y., Tanaka H., Shigenobu K.: Inhibition of T-type and L-type Ca2+ currents by aranidipine, a novel dihydropyridine Ca2+ antagonist. Pharmacology 61:57-61 (2000)
90) Naito A., Ohtake Y., Hasegawa H., Fukaya AY., Kurasawa T., Naito K., Matsukawa H., Oguma T., Ezure Y., Tsuriya Y., Tanaka H., Koike K., Shigenobu K.: Pharmacological profile of VP-343, a novel selective vasopressin V2 receptor antagonist in rats. Biol. Pharm. Bull. 23:182-189 (2000)
89) Nishimaru K., Tanaka Y, Tanaka H., Shigenobu K.: Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sciences 66: 607-615 (2000)
88) Masumiya H., Matsuda T., Tanaka Y., Tanaka H., Shigenobu K.: Possible requirement of phosphonate moiety for efonidipine effects on the sino-atrial node action potential. Life Sciences 66: 239-244 (2000)

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