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東邦大学 薬学部薬物学教室  
田中 光 行方 衣由紀 M口正悟
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田中 光 <たなか ひかる> 東邦大学薬学部教授、薬学博士

原著論文 1999年−1990年

1999
87) Noguchi K., Karasawa Y., Isobe Y., Fukushima K., Tanaka H., Shigenobu K.: The effects of haloperidol on action potential parameters of isolated rabbit ventricular muscle. Res. Comm. Biol. Psychol. Psychiat. 24: 21-33 (1999).
86) Masumiya H., Kase J., Tanaka Y., Tanaka H., Shigenobu K.: Effects of mibefradil, a selective T-type Ca2+ channel antagonist on sino-atrial node and ventricular myocardia. Res. Comm. Mol. Path. Pharmacol. 104: 321-329 (1999)
85) Tanaka Y., Mochizuki Y., Tanaka H., Shigenobu K.: Significant role of neuronal non-N-type calcium channels in the sympathetic neurogenic contraction of rat mesenteric artery. Br. J. Pharmacol. 128: 1602-1608 (1999)
84) Takahashi M., Misawa Y., Watanabe N., Kawanishi T., Tanaka H., Shigenobu K., Kobayashi Y.: Role of P-glycoprotein in human natural killer-like cell line mediated cytotoxicity. Exp. Cell Res. 252: 396-402 (1999)
83) Tanaka Y., Mochizuki Y., Hirano H., Aida M., Tanaka H., Toro L., Shigenobu K.: Role of maxi K channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery. Eur. J. Pharmacol. 383: 291-296 (1999)
82) Nishimaru K., Sekine T., Tanaka Y., Tanaka H., Shigenobu K.: Temperature sensitive effects of a-adrenoceptor stimulation in mouse ventricular myocardia. Res. Comm. Mol. Path. Pharmacol. 104: 173-180 (1999)
81) Tanaka H., Ichikawa T., Matsui S., Okazaki K., Masumiya H., Kawanishi T., Shigenobu K.: Calcium channel antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig myocardium. Res. Comm. Mol. Path. Pharmacol. 104: 13-21 (1999)
80) Tanaka Y., Yamaki F., Hirano H., Otsuka A., Tanaka H., Shigenobu K.: Endothelium is involved in the vasorelaxation by an ATP-sensitive K+ channel opener, NIP-121. Eur. J. Pharmacol. 366: R9-10 (1999)
79) Tanaka Y., Kaneko H., Tanaka H., Shigenobu K.: Pharmacologic characteristics of non-prostanoid, non-nitric oxide mediated and endothelium-dependent relaxation of guinea-pig aorta in response to substance P. Res. Comm. Mol. Pathol. Pharmacol. 103: 65-81 (1999)
78) Taniguchi H., Tanaka Y., Hirano H., Tanaka H., Shigenobu K.: Evidence for a contribution of store-operated Ca2+ channels to NO-mediated endothelium-dependent relaxation of guinea-pig aorta in response to a Ca2+ ionophore, A23187. Naunyn Schmied. Arch. Pharmacol. 360: 69-79 (1999)
77) Taniguchi H., Hirano H., Tanaka Y., Tanaka H., Shigenobu K.: Possible involvement of Ca2++ entry and its pharmacological characteristics responsible for endothelium-dependent, NO-mediated relaxation induced by thapsigargin in guinea-pig aorta. J Pharm. Pharmacol. 51:831-840 (1999)
76) Tanaka Y., Otsuka A., Tanaka H., Shigenobu K.: Glycyrrhetinic acid-sensitive mechanism does not make a major contribution to non-prostanoid, non-nitric oxide mediated endothelium dependent relaxation of rat mesenteric artery in response to acetylcholine. Res. Comm. Mol. Path. Pharm. 103: 227-239 (1999)
75) Masumiya H., Saitoh T., Tanaka Y., Horie S., Aimi N., Takayama H., Tanaka H., Shigenobu K.: Effects of hirsutine and dihydrocorynantheine on the action potentials of sino-atrial node, atrium and ventricle. Life Sciences 65: 2333-2341 (1999)
74) Sekine T., Kusano H., Nishimaru K., Tanaka Y., Tanaka H., Shigenobu K.: Developmental conversion of inotropism by endothelin I and angiotensin II from positive to negative in mice. Eur. J. Pharmacol. 374: 411-415 (1999)

1998
73) Sekine T., Kawanishi T., Tanaka H., Shigenobu K.: Cardioprotective effect and fluorescence profiles of AHC-93, a dihydropyridine compound with inhibitory effect on Cl- but not Ca2+ current. Res. Comm. Pharmacol. Toxicol. 3: 1-10 (1998)
72) Tanaka H., Sekine T., Nishimaru K., Shigenobu K.: Role of sarcoplasmic reticulum in myocardial contraction of neonatal and adult mice. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 120:431-438 (1998)
71) Masumiya H., Shijyuku T, Tanaka H., Shigenobu K.: Inhibition of myocardial L- and T- type Ca2+ currents by efonidipine: possible mechanism for its chronotropism. Eur. J. Pharmacol. 349: 351-357 (1998)
70) Tanaka Y., Aida M., Tanaka H., Shigenobu K., Toro L.: Involvement of maxi-K(Ca) channel activation in atrial natriuretic peptide-induced vasorelaxation. Naunyn-Schmied. Arch. Pharmacol. 357: 705-708 (1998)
69) Saito W., Aida M., Sasaki M., Saito Y., Tanaka Y., Tanaka H., Shigenobu K.: Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta. Life Sci. 62: 2171-2179 (1998)
68) Tanaka H., Matsui S., Shigenobu K.: Cardioprotective effects of beraprost sodium against experimental ischemia and reperfusion as compared with propranolol and diltiazem. Res. Comm. Mol. Pathol. Pharmacol. 99: 321-327 (1998)
67) Tanaka H., Sekine T., Kawanishi T., Nakamura R., Shigenobu K.: Intrasarcomere [Ca2+] gradients and their spatio-temporal relation to Ca2+ sparks in rat cardiomyocytes. J. Physiol. 508: 145-152 (1998)
66) Takahashi S., Tanaka H., Shigenobu K.: Effects of ryanodine and cyclopiazonic acid on skinned fibers of ventricular myocardium from neonatal rats. Gen. Pharmacol. 30:745-748 (1998)
65) Saito W., Noguchi K., Okazaki K., Matsuda T., Kato Y., Tanaka H., Shigenobu K.: Temperature sensitive effects of potassium channel openers on isolated guinea-pig myocardium and aorta. J. Cardiovasc. Pharmacol. 31: 327-329 (1998)
64) Noguchi K., Shijuku T., Nakasone C., Takahashi K., Higuchi S., Tanaka Y., Tanaka H., Shigenobu K.: Possible involvement of nitric oxide in the negative chronotropic effect of CD-832, a novel dihydropyridine derivative. Life Sci., 62: 897-903 (1998)

1997
63) Saito W., Tanaka H., Shigenobu K.: Inhibitory effects of potassium channel openers on contractions induced by sympathetic nerve stimulation in rat vas deferens. Res. Comm. Mol. Pathol. Pharmacol. 2: 229-239 (1997)
62) Tanaka H., Nishimaru K., Sekine T., Shijuku T., Shigenobu K.: Effects of terfenadine, betotastine and ketotifen on the action potential and membrane currents in isolated guinea-pig myocardium. Res. Comm. Pharmacol. Toxicol. 2: 163-174 (1997)
61) Saito W., Tanaka H., Shigenobu K.: Possible involvement of ATP-sensitive potasssium channels in the hypotensive and endothelium-dependent vasorelaxant effects of beraprost, a stable PGI2 analog. Res. Comm. Pharmacol. Toxicol. 2:137-147 (1997)
60) Noguchi K., Masumiya H., Takahashi K., Kaneko K., Higuchi S., Tanaka H., Shigenobu K.: Comparative effects of gallopamil and verapamil on the mechanical and electrophysiological parameters of isolated guinea-pig myocardium. Can. J. Physiol. Pharamacol. 75: 1316-1321 (1997)
59) Tanaka H., Taniguchi H., Agata N., Tanaka Y., Shigenobu K.: Endothelium mediated vasorelaxant effects of Ca2+-ATPase inhibitors on thoracic aorta from neonatal and adult guinea pigs. Res. Comm. Mol. Pathol. Pharmacol. 98: 115-126 (1997)
58) Agata N., Tanaka H., Shigenobu K.: Difference in the endothelium mediated effects of A23187 on thoracic aorta between neonatal and adult guinea pigs. Res. Comm. Mol. Pathol. Pharmacol. 98: 53-65 (1997)
57) Noguchi K., Tanaka H., Shigenobu K.: Myocardial action potential prolongation by calcium channel activation under calcium free-EGTA condition in guinea pigs: regional and developmental variations. Res. Comm. Mol. Pathol. Pharmacol. 97: 325-334 (1997)
56) Masumiya H., Tanaka H., Shigenobu K.: Effects of calcium antagonists on the action potential configuration of rabbit sinus node: selective prolongation of late phase 4 depolarization by efonidipine. Eur. J. Pharmacol. 335: 15-21 (1997)
55) Tanaka H., Sekine T., Terada M., Shigenobu K.: Cardioprotective effect against ischemia-reperfusion injury of AHC-52, a dihydropyridine compound with inhibitory effect on Cl- but not Ca2+ current. Naunyn-Schmeid. Arch. Pharmacol. 356:853-855 (1997)
54) Kamata K., Satoh T., Tanaka H., Shigenobu K.: Changes in electrophysiological and mechanical responses of the rat papillary muscle to a- and b-agonist in streptozotocin-induced diabetes. Can. J. Physiol. Pharmacol. Can. J. Physiol. Pharmacol. 75: 781-788 (1997)
53) Takahashi S., Tanaka H., Hano Y., Ito K., Nomura T., Shigenobu K.: Hypotensive effect in rats of hydrophilic extract from Terminalia-arjuna containing tannin-related compounds. Phytother. Res. 11: 424-427 (1997)
52) Tanaka H., Nishimaru K., Sekine T., Kawanishi T., Nakamura R., Yamagaki K., Shigenobu K.: Two dimensional millisecond analysis of intracellular Ca2+ sparks in cardiomyocytes as revealed by rapid scanning confocal microscopy: increase in amplitude by isoproterenol. Biochem. Biophys. Res. Comm. 233: 413-418 (1997)
51) Kobayashi Y., Yamashiro T., Jinnai T., Watanabe N., Kawanishi T., Tanaka H. Shigenobu K.: Target cell-induced calcium signals in natural killer cells as revealed by confocal fluorescence microscopy. Exp. Cell Res. 232: 42-46 (1997)

1996
50) Takahashi S., Adachi M., Tanaka H., Shigenobu K.: Effects of 8-(N,N-diethylamino) octyl-3,4,5-trimethoxy benzoate-hydrochloride (TMB-8) on skinned myocardial fibers of the rat: reversible inhibition of calcium release from the sarcoplasmic reticulum. Naunyn-Schmied. Arch. Pharmacol. 354: 650-665 (1996)
49) Tanaka H., Matsui S., Kawanishi T., Shigenobu K.: Use of chloride blockers: a novel approach for cardioprotection against ischemia-reperfusion damage. J. Pharmacol. Exp. Ther. 278: 854-861 (1996)
48) Kato Y., Masumiya H., Agata N., Tanaka H., Shigenobu K.: Developmental changes in action potential and membrane currents in fetal, neonatal and adult guinea-pig ventricular myocytes. J. Mol. Cell Cardiol. 28: 1515-1522 (1996)
47) Noguchi K., Masumiya H., Sasaki T., Takahashi K., Araki H., Higuchi S., Tanaka H., Shigenobu K.: Relative selectivity for negative chronotropic and inotropic effects of a novel dihydropyridine derivative, CD-832. In vitro comparison with various Ca2+ channel antagonists. Eur. J. Pharmacol. 308:53-59 (1996)
46) Tanaka H., Okazaki K, Shigenobu K.: Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium channel opener, during ischemia and reperfusion in coronary perfused guinea-pig myocardium. J. Cardiovasc. Pharmacol. 27:695-701 (1996)
45) Tanaka H., Kawanishi T., Matsuda T., Takahashi M., Shigenobu K.: Intracellular free Ca2+ movements in cultured cardiac myocytes as revealed by rapid scanning confocal microscopy. J. Cardiovas. Pharmacol. 27:761-769 (1996)
44) Tanaka H., Masumiya H., Sekine T., Shijuku T., Sugahara M., Taniguchi H., Terada M., Saito W., Shigenobu K.: Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem. Gen. Pharmacol. 27:695-701 (1996)
43) Tanaka H., Masumiya H., Kato K., Shigenobu K.: Inhibitory effects of terfenadine on the rising phase of action potentials and sinus rates in isolated guinea-pig myocardium. Gen Pharmacol. 27:337-340 (1996)
42) Ueno Y., Okazaki S., Isogaya M., Nishio S., Tanaka H., Kato K., Shigenobu K.: Positive inotropic and chronotropic effects of beraprost sodium, a stable analogue of prostacyclin, in isolated guinea-pig myocardium. Gen. Pharmacol. 27:101-103 (1996)
41) Tanaka H., Kato Y., Kawanishi T., Nakamura R., Shigenobu K.: Restricted propagation of cytoplasmic Ca2+ oscillation into the nucleus in cardiac myocytes as revealed by rapid scanning confocal microscopy and indo-1. Jpn. J. Pharmacol. 70:235-242 (1996)

1995
40) Tanaka H., Matsuda T., Adachi M., Shigenobu K.: Effect of sympathectomy on inotropic responsiveness to alpha-adrenoceptor stimulation in developing mouse myocardia. Can. J. Physiol. Pharmacol. 73:1285-1288 (1995)
39) Tanaka H., Uesato N., Shigenobu K.: Inotropic effects of histamine on developing chick heart: release of transmitters from autonomic nerve terminals. Naunyn-Schmied. Arch. Pharmacol. 352:626-630 (1995)
38) Matsuda T., Okazaki K., Kato Y., Tanaka H., Shigenobu K.: K+ channel opening properties of a novel compound, NIP-121, in guinea-pig myocardium as compared with cromakalim. J. Cardiovasc. Pharmacol. 26:608-613 (1995)
37) Takahashi S., Kato Y., Adachi M., Agata N., Tanaka H., Shigenobu K.: Effects of cyclopiazonic acid on rat myocardium: inhibition of calcium uptake into sarcoplasmic reticulum. J. Pharmacol. Exp. Ther. 272:1095-1100 (1995)
36) Tanaka H., Uesato N., Shigenobu K.: Chronotropic and inotropic effects of histamine on developing chick heart: differential mechanisms between embryonic and hatched myocardia. Naunyn-Schmied. Arch. Pharmacol. 351:391-397 (1995)
35) Tanaka H., Manita S., Matsuda T., Adachi M., Shigenobu K.: Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate. Br. J. Pharmacol. 114:673-677 (1995)
34) Tanaka H., Takagi N., Shigenobu K.: Difference in excitation contraction mechanisms between atrial and ventricular myocardia of hatched chicks. Gen. Pharmacol. 26:45-49 (1995)
33) Tanaka H., Noguchi K., Shigenobu K.: Myocardial action potential prolongation by calcium channel activation under calcium free-EGTA condition in rats: regional and developmental variations. Gen. Pharmacol. 26:39-43 (1995)

1994
32) Agata N., Tanaka H., Shigenobu K.: Inotropic effects of ryanodine and nicardipine on fetal, neonatal and adult guinea-pig myocardium. Eur. J. Pharmacol. 260:47-55 (1994)
31) Kobayashi Y, Nagatake H., Yamamoto T., Watanabe N., Tanaka H., Shigenobu K., Tsuruo T.: Expression and function of multidrug resistance P-glycoprotein in a cultured natural killer cell-rich population revealed by MRK16 monoclonal antibody and AHC-52. Biochem. Pharmacol. 48:1641-1646 (1994)
30) Tanaka H., Noguchi K., Shigenobu K.: Myocardial action potential prolongation by calcium channel activation under calcium free-EGTA condition in guinea pigs and rats. Gen. Pharmacol. 25:475-480 (1994)
29) Tanaka H., Takagi N., Shigenobu K.: Effects of low sodium, ouabain and amiloride on chick myocardial contraction. Gen. Pharmacol. 25:457-460 (1994)
28) Tanaka H., Manita S., Shigenobu K.: Increased sensitivity of neonatal mouse myocardium to autonomic transmitters. J. Autonom. Pharmacol. 14:123-128 (1994)
27) Agata N., Tanaka H., Shigenobu K. Effects of tetrodotoxin and low sodium on action potential plateau of ventricular myocardium from neonatal and adult guinea-pigs. Comp. Biochem. Physiol.107A:459-461 (1994)
26) Tanaka H., Matsuda T., Kawada H., Shigenobu K.: Postnatal decrease in chronotropic sensitivity to acetylcholine in rat heart. Gen. Pharmacol. 25:157-160 (1994)
25) Agata N., Kato Y. Tanaka H., Shigenobu K.: Differential effects of hypoxia on electrical and mechanical activities of isolated ventricular muscles from fetal and adult guinea-pigs. Gen. Pharmacol. 25:15-18 (1994)

1993
24) Tanaka H., Takagi N, Shigenobu K.: Effects of ryanodine and calcium antagonists on embryonic and hatched chick myocardium. J. Dev. Physiol. 19:235-240 (1993)
23) Agata N., Tanaka H., Shigenobu K.: Developmental changes in action potential properties of the guinea-pig myocardium. Acta Physiol. Scand. 149:331-337 (1993)
22) Agata N.,Tanaka H., Shigenobu K.: Possible action of cyclopiazonic acid on myocardial sarcoplasmic reticulum: inotropic effects on neonatal and adult rat heart. Br. J. Pharmacol. 108:571-572 (1993)
21) Tanaka H., Takahashi S., Shigenobu K.: Hypotensive effect of bopindolol in pithed rats. Gen. Pharmacol. 24:373-375 (1993)
20) Tanaka H., Ikeda U, Shigenobu K.: Positive chronotropic and inotropic effects of lysophosphatidylcholine are mediated by norepinephrine released from sympathetic nerve terminals. Gen. Pharmacol. 24:239-241 (1993)

1992
19) Agata N., Tanaka H., Shigenobu K.: Effect of manganese on neonatal and adult rat heart: initial depression and late augmentation of contractile force. Eur. J. Pharmacol. 222:223-226 (1992)
18) Ikeya K., Saito K., Hayashi K.,Tanaka H., Hagiwara Y., Yoshida M., Yamauchi A., Fukuyama Y., Ishiguro T., Eguchi C., Ozawa E.: Molecular genetic and immunological analysis of dystrophin of a young patient with X-linked muscular dystrophy. Am. J. Med. Gen. 43:580-587 (1992)
17) Saito K., Yoshida M., Tanaka H.: Sensitivity of cultured and skinned chick myotube to calcium, strontium and barium ions examined by recording isometric contractions. J. Cell. Physiol. 150:45-51 (1992)

1991
16) Tanaka H., Hayashi K., Ozawa E.: Positive immunostaining with dystrophin antibodies in mdx skeletal muscle. Proc. Japan. Acad. 67B:148-152 (1991)
15) Tanaka H., Ishiguro T., Eguchi C., Saito K., Ozawa E.: Expression of a dystrophin-related protein associated with the muscle cell membrane. Histochemistry 96:1-5 (1991)

1990
14) Tanaka H., Ozawa E.: Expression of dystrophin mRNA and the protein in the developing rat heart. Biochem. Biophys. Res. Comm. 172:824-829 (1990)
13) Tanaka H., Ozawa E.: Developmental expression of dystrophin on the rat myocardial cell membrane. Histochemistry 94:449-453 (1990)
12) Tanaka H.,Ikeya K., Ozawa E.: Difference in the expression pattern of dystrophin between the skeletal and cardiac muscles of the mdx carrier mice. Histochemistry 93:447-452 (1990)
11) Tanaka H., Shigenobu K.: Rat heart organ culture for the study of trophic substances involved in the maintenance of normal sensitivity to norepinephrine: possible involvement of cAMP and search for other factors. Can. J. Physiol. Pharmacol. 68:898-902 (1990)
10) Tanaka H., Shigenobu K.: Role of b-adrenoceptor-adenylate cyclase system in the developmental decrease in sensitivity to isoproterenol in fetal and neonatal rat heart. Br. J. Pharmacol. 100:138-142 (1990)

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