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田中 光 <たなか ひかる> 東邦大学薬学部教授、薬学博士
最新-2020 | 2019-2010 | 2009-2000 | 1999-1990 | 1989- 最新-2015 最新-2015 最新-2006
最新-2020 | 2019-2010 | 2009-2000 | 1999-1992 | 1991-
原著論文 1999年−1990年
1999
87) |
Noguchi K., Karasawa Y., Isobe Y., Fukushima
K., Tanaka H., Shigenobu K.: The effects of haloperidol on
action potential parameters of isolated rabbit ventricular muscle.
Res. Comm. Biol. Psychol. Psychiat. 24: 21-33 (1999). |
86) |
Masumiya H., Kase J., Tanaka Y., Tanaka
H., Shigenobu K.: Effects of mibefradil, a selective T-type Ca2+
channel antagonist on sino-atrial node and ventricular myocardia.
Res. Comm. Mol. Path. Pharmacol. 104: 321-329 (1999) |
85) |
Tanaka Y., Mochizuki Y., Tanaka H.,
Shigenobu K.: Significant role of neuronal non-N-type calcium channels
in the sympathetic neurogenic contraction of rat mesenteric artery.
Br. J. Pharmacol. 128: 1602-1608 (1999) |
84) |
Takahashi M., Misawa Y., Watanabe N.,
Kawanishi T., Tanaka H., Shigenobu K., Kobayashi Y.: Role of
P-glycoprotein in human natural killer-like cell line mediated cytotoxicity.
Exp. Cell Res. 252: 396-402 (1999) |
83) |
Tanaka Y., Mochizuki Y., Hirano H., Aida
M., Tanaka H., Toro L., Shigenobu K.: Role of maxi K channels
in vasoactive intestinal peptide-induced relaxation of rat mesenteric
artery. Eur. J. Pharmacol. 383: 291-296 (1999) |
82) |
Nishimaru K., Sekine T., Tanaka Y., Tanaka
H., Shigenobu K.: Temperature sensitive effects of a-adrenoceptor
stimulation in mouse ventricular myocardia. Res. Comm. Mol. Path.
Pharmacol. 104: 173-180 (1999) |
81) |
Tanaka H., Ichikawa T., Matsui
S., Okazaki K., Masumiya H., Kawanishi T., Shigenobu K.: Calcium channel
antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig
myocardium. Res. Comm. Mol. Path. Pharmacol. 104: 13-21 (1999) |
80) |
Tanaka Y., Yamaki F., Hirano H., Otsuka
A., Tanaka H., Shigenobu K.: Endothelium is involved in the
vasorelaxation by an ATP-sensitive K+ channel opener, NIP-121. Eur.
J. Pharmacol. 366: R9-10 (1999) |
79) |
Tanaka Y., Kaneko H., Tanaka H.,
Shigenobu K.: Pharmacologic characteristics of non-prostanoid, non-nitric
oxide mediated and endothelium-dependent relaxation of guinea-pig
aorta in response to substance P. Res. Comm. Mol. Pathol. Pharmacol.
103: 65-81 (1999) |
78) |
Taniguchi H., Tanaka Y., Hirano H., Tanaka
H., Shigenobu K.: Evidence for a contribution of store-operated
Ca2+ channels to NO-mediated endothelium-dependent relaxation of guinea-pig
aorta in response to a Ca2+ ionophore, A23187. Naunyn Schmied. Arch.
Pharmacol. 360: 69-79 (1999) |
77) |
Taniguchi H., Hirano H., Tanaka Y., Tanaka
H., Shigenobu K.: Possible involvement of Ca2++ entry and its
pharmacological characteristics responsible for endothelium-dependent,
NO-mediated relaxation induced by thapsigargin in guinea-pig aorta.
J Pharm. Pharmacol. 51:831-840 (1999) |
76) |
Tanaka Y., Otsuka A., Tanaka H.,
Shigenobu K.: Glycyrrhetinic acid-sensitive mechanism does not make
a major contribution to non-prostanoid, non-nitric oxide mediated
endothelium dependent relaxation of rat mesenteric artery in response
to acetylcholine. Res. Comm. Mol. Path. Pharm. 103: 227-239 (1999) |
75) |
Masumiya H., Saitoh T., Tanaka Y., Horie
S., Aimi N., Takayama H., Tanaka H., Shigenobu K.: Effects
of hirsutine and dihydrocorynantheine on the action potentials of
sino-atrial node, atrium and ventricle. Life Sciences 65: 2333-2341
(1999) |
74) |
Sekine T., Kusano H., Nishimaru K., Tanaka
Y., Tanaka H., Shigenobu K.: Developmental conversion of inotropism
by endothelin I and angiotensin II from positive to negative in mice.
Eur. J. Pharmacol. 374: 411-415 (1999) |
▲
1998
73) |
Sekine T., Kawanishi T., Tanaka H.,
Shigenobu K.: Cardioprotective effect and fluorescence profiles of
AHC-93, a dihydropyridine compound with inhibitory effect on Cl- but
not Ca2+ current. Res. Comm. Pharmacol. Toxicol. 3: 1-10 (1998) |
72) |
Tanaka H., Sekine T., Nishimaru
K., Shigenobu K.: Role of sarcoplasmic reticulum in myocardial contraction
of neonatal and adult mice. Comp. Biochem. Physiol. A Mol. Integr.
Physiol. 120:431-438 (1998) |
71) |
Masumiya H., Shijyuku T, Tanaka H.,
Shigenobu K.: Inhibition of myocardial L- and T- type Ca2+ currents
by efonidipine: possible mechanism for its chronotropism. Eur. J.
Pharmacol. 349: 351-357 (1998) |
70) |
Tanaka Y., Aida M., Tanaka H.,
Shigenobu K., Toro L.: Involvement of maxi-K(Ca) channel activation
in atrial natriuretic peptide-induced vasorelaxation. Naunyn-Schmied.
Arch. Pharmacol. 357: 705-708 (1998) |
69) |
Saito W., Aida M., Sasaki M., Saito Y.,
Tanaka Y., Tanaka H., Shigenobu K.: Differential sensitivity
to ATP-sensitive potassium channel openers of norepinephrine-induced
contraction of guinea pig and rat aorta. Life Sci. 62: 2171-2179 (1998) |
68) |
Tanaka H., Matsui S., Shigenobu
K.: Cardioprotective effects of beraprost sodium against experimental
ischemia and reperfusion as compared with propranolol and diltiazem.
Res. Comm. Mol. Pathol. Pharmacol. 99: 321-327 (1998) |
67) |
Tanaka H., Sekine T., Kawanishi
T., Nakamura R., Shigenobu K.: Intrasarcomere [Ca2+] gradients and
their spatio-temporal relation to Ca2+ sparks in rat cardiomyocytes.
J. Physiol. 508: 145-152 (1998) |
66) |
Takahashi S., Tanaka H., Shigenobu
K.: Effects of ryanodine and cyclopiazonic acid on skinned fibers
of ventricular myocardium from neonatal rats. Gen. Pharmacol. 30:745-748
(1998) |
65) |
Saito W., Noguchi K., Okazaki K., Matsuda
T., Kato Y., Tanaka H., Shigenobu K.: Temperature sensitive
effects of potassium channel openers on isolated guinea-pig myocardium
and aorta. J. Cardiovasc. Pharmacol. 31: 327-329 (1998) |
64) |
Noguchi K., Shijuku T., Nakasone C., Takahashi
K., Higuchi S., Tanaka Y., Tanaka H., Shigenobu K.: Possible
involvement of nitric oxide in the negative chronotropic effect of
CD-832, a novel dihydropyridine derivative. Life Sci., 62: 897-903
(1998) |
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1997
63) |
Saito W., Tanaka H., Shigenobu
K.: Inhibitory effects of potassium channel openers on contractions
induced by sympathetic nerve stimulation in rat vas deferens. Res.
Comm. Mol. Pathol. Pharmacol. 2: 229-239 (1997) |
62) |
Tanaka H., Nishimaru K., Sekine
T., Shijuku T., Shigenobu K.: Effects of terfenadine, betotastine
and ketotifen on the action potential and membrane currents in isolated
guinea-pig myocardium. Res. Comm. Pharmacol. Toxicol. 2: 163-174 (1997) |
61) |
Saito W., Tanaka H., Shigenobu
K.: Possible involvement of ATP-sensitive potasssium channels in the
hypotensive and endothelium-dependent vasorelaxant effects of beraprost,
a stable PGI2 analog. Res. Comm. Pharmacol. Toxicol. 2:137-147 (1997) |
60) |
Noguchi K., Masumiya H., Takahashi K.,
Kaneko K., Higuchi S., Tanaka H., Shigenobu K.: Comparative
effects of gallopamil and verapamil on the mechanical and electrophysiological
parameters of isolated guinea-pig myocardium. Can. J. Physiol. Pharamacol.
75: 1316-1321 (1997) |
59) |
Tanaka H., Taniguchi H., Agata
N., Tanaka Y., Shigenobu K.: Endothelium mediated vasorelaxant effects
of Ca2+-ATPase inhibitors on thoracic aorta from neonatal and adult
guinea pigs. Res. Comm. Mol. Pathol. Pharmacol. 98: 115-126 (1997) |
58) |
Agata N., Tanaka H., Shigenobu
K.: Difference in the endothelium mediated effects of A23187 on thoracic
aorta between neonatal and adult guinea pigs. Res. Comm. Mol. Pathol.
Pharmacol. 98: 53-65 (1997) |
57) |
Noguchi K., Tanaka H., Shigenobu
K.: Myocardial action potential prolongation by calcium channel activation
under calcium free-EGTA condition in guinea pigs: regional and developmental
variations. Res. Comm. Mol. Pathol. Pharmacol. 97: 325-334 (1997) |
56) |
Masumiya H., Tanaka H., Shigenobu
K.: Effects of calcium antagonists on the action potential configuration
of rabbit sinus node: selective prolongation of late phase 4 depolarization
by efonidipine. Eur. J. Pharmacol. 335: 15-21 (1997) |
55) |
Tanaka H., Sekine T., Terada M.,
Shigenobu K.: Cardioprotective effect against ischemia-reperfusion
injury of AHC-52, a dihydropyridine compound with inhibitory effect
on Cl- but not Ca2+ current. Naunyn-Schmeid. Arch. Pharmacol. 356:853-855
(1997) |
54) |
Kamata K., Satoh T., Tanaka H.,
Shigenobu K.: Changes in electrophysiological and mechanical responses
of the rat papillary muscle to a- and b-agonist in streptozotocin-induced
diabetes. Can. J. Physiol. Pharmacol. Can. J. Physiol. Pharmacol.
75: 781-788 (1997) |
53) |
Takahashi S., Tanaka H., Hano Y.,
Ito K., Nomura T., Shigenobu K.: Hypotensive effect in rats of hydrophilic
extract from Terminalia-arjuna containing tannin-related compounds.
Phytother. Res. 11: 424-427 (1997) |
52) |
Tanaka H., Nishimaru K., Sekine
T., Kawanishi T., Nakamura R., Yamagaki K., Shigenobu K.: Two dimensional
millisecond analysis of intracellular Ca2+ sparks in cardiomyocytes
as revealed by rapid scanning confocal microscopy: increase in amplitude
by isoproterenol. Biochem. Biophys. Res. Comm. 233: 413-418 (1997) |
51) |
Kobayashi Y., Yamashiro T., Jinnai T.,
Watanabe N., Kawanishi T., Tanaka H. Shigenobu K.: Target cell-induced
calcium signals in natural killer cells as revealed by confocal fluorescence
microscopy. Exp. Cell Res. 232: 42-46 (1997) |
▲
1996
50) |
Takahashi S., Adachi M., Tanaka H.,
Shigenobu K.: Effects of 8-(N,N-diethylamino) octyl-3,4,5-trimethoxy
benzoate-hydrochloride (TMB-8) on skinned myocardial fibers of the
rat: reversible inhibition of calcium release from the sarcoplasmic
reticulum. Naunyn-Schmied. Arch. Pharmacol. 354: 650-665 (1996) |
49) |
Tanaka H., Matsui S., Kawanishi
T., Shigenobu K.: Use of chloride blockers: a novel approach for cardioprotection
against ischemia-reperfusion damage. J. Pharmacol. Exp. Ther. 278:
854-861 (1996) |
48) |
Kato Y., Masumiya H., Agata N., Tanaka
H., Shigenobu K.: Developmental changes in action potential and
membrane currents in fetal, neonatal and adult guinea-pig ventricular
myocytes. J. Mol. Cell Cardiol. 28: 1515-1522 (1996) |
47) |
Noguchi K., Masumiya H., Sasaki T., Takahashi
K., Araki H., Higuchi S., Tanaka H., Shigenobu K.: Relative
selectivity for negative chronotropic and inotropic effects of a novel
dihydropyridine derivative, CD-832. In vitro comparison with various
Ca2+ channel antagonists. Eur. J. Pharmacol. 308:53-59 (1996) |
46) |
Tanaka H., Okazaki K, Shigenobu
K.: Cardioprotective effects of NIP-121, a novel ATP-sensitive potassium
channel opener, during ischemia and reperfusion in coronary perfused
guinea-pig myocardium. J. Cardiovasc. Pharmacol. 27:695-701 (1996) |
45) |
Tanaka H., Kawanishi T., Matsuda
T., Takahashi M., Shigenobu K.: Intracellular free Ca2+ movements
in cultured cardiac myocytes as revealed by rapid scanning confocal
microscopy. J. Cardiovas. Pharmacol. 27:761-769 (1996) |
44) |
Tanaka H., Masumiya H., Sekine
T., Shijuku T., Sugahara M., Taniguchi H., Terada M., Saito W., Shigenobu
K.: Myocardial and vascular effects of efonidipine in vitro as compared
with nifedipine, verapamil and diltiazem. Gen. Pharmacol. 27:695-701
(1996) |
43) |
Tanaka H., Masumiya H., Kato K.,
Shigenobu K.: Inhibitory effects of terfenadine on the rising phase
of action potentials and sinus rates in isolated guinea-pig myocardium.
Gen Pharmacol. 27:337-340 (1996) |
42) |
Ueno Y., Okazaki S., Isogaya M., Nishio
S., Tanaka H., Kato K., Shigenobu K.: Positive inotropic and
chronotropic effects of beraprost sodium, a stable analogue of prostacyclin,
in isolated guinea-pig myocardium. Gen. Pharmacol. 27:101-103 (1996) |
41) |
Tanaka H., Kato Y., Kawanishi T.,
Nakamura R., Shigenobu K.: Restricted propagation of cytoplasmic Ca2+
oscillation into the nucleus in cardiac myocytes as revealed by rapid
scanning confocal microscopy and indo-1. Jpn. J. Pharmacol. 70:235-242
(1996) |
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1995
40) |
Tanaka H., Matsuda T., Adachi M.,
Shigenobu K.: Effect of sympathectomy on inotropic responsiveness
to alpha-adrenoceptor stimulation in developing mouse myocardia. Can.
J. Physiol. Pharmacol. 73:1285-1288 (1995) |
39) |
Tanaka H., Uesato N., Shigenobu
K.: Inotropic effects of histamine on developing chick heart: release
of transmitters from autonomic nerve terminals. Naunyn-Schmied. Arch.
Pharmacol. 352:626-630 (1995) |
38) |
Matsuda T., Okazaki K., Kato Y., Tanaka
H., Shigenobu K.: K+ channel opening properties of a novel compound,
NIP-121, in guinea-pig myocardium as compared with cromakalim. J.
Cardiovasc. Pharmacol. 26:608-613 (1995) |
37) |
Takahashi S., Kato Y., Adachi M., Agata
N., Tanaka H., Shigenobu K.: Effects of cyclopiazonic acid
on rat myocardium: inhibition of calcium uptake into sarcoplasmic
reticulum. J. Pharmacol. Exp. Ther. 272:1095-1100 (1995) |
36) |
Tanaka H., Uesato N., Shigenobu
K.: Chronotropic and inotropic effects of histamine on developing
chick heart: differential mechanisms between embryonic and hatched
myocardia. Naunyn-Schmied. Arch. Pharmacol. 351:391-397 (1995) |
35) |
Tanaka H., Manita S., Matsuda T.,
Adachi M., Shigenobu K.: Sustained negative inotropism mediated by
alpha-adrenoceptors in adult mouse myocardia: developmental conversion
from positive response in the neonate. Br. J. Pharmacol. 114:673-677
(1995) |
34) |
Tanaka H., Takagi N., Shigenobu
K.: Difference in excitation contraction mechanisms between atrial
and ventricular myocardia of hatched chicks. Gen. Pharmacol. 26:45-49
(1995) |
33) |
Tanaka H., Noguchi K., Shigenobu
K.: Myocardial action potential prolongation by calcium channel activation
under calcium free-EGTA condition in rats: regional and developmental
variations. Gen. Pharmacol. 26:39-43 (1995) |
▲
1994
32) |
Agata N., Tanaka H., Shigenobu
K.: Inotropic effects of ryanodine and nicardipine on fetal, neonatal
and adult guinea-pig myocardium. Eur. J. Pharmacol. 260:47-55 (1994) |
31) |
Kobayashi Y, Nagatake H., Yamamoto T.,
Watanabe N., Tanaka H., Shigenobu K., Tsuruo T.: Expression
and function of multidrug resistance P-glycoprotein in a cultured
natural killer cell-rich population revealed by MRK16 monoclonal antibody
and AHC-52. Biochem. Pharmacol. 48:1641-1646 (1994) |
30) |
Tanaka H., Noguchi K., Shigenobu
K.: Myocardial action potential prolongation by calcium channel activation
under calcium free-EGTA condition in guinea pigs and rats. Gen. Pharmacol.
25:475-480 (1994) |
29) |
Tanaka H., Takagi N., Shigenobu
K.: Effects of low sodium, ouabain and amiloride on chick myocardial
contraction. Gen. Pharmacol. 25:457-460 (1994) |
28) |
Tanaka H., Manita S., Shigenobu
K.: Increased sensitivity of neonatal mouse myocardium to autonomic
transmitters. J. Autonom. Pharmacol. 14:123-128 (1994) |
27) |
Agata N., Tanaka H., Shigenobu
K. Effects of tetrodotoxin and low sodium on action potential plateau
of ventricular myocardium from neonatal and adult guinea-pigs. Comp.
Biochem. Physiol.107A:459-461 (1994) |
26) |
Tanaka H., Matsuda T., Kawada H.,
Shigenobu K.: Postnatal decrease in chronotropic sensitivity to acetylcholine
in rat heart. Gen. Pharmacol. 25:157-160 (1994) |
25) |
Agata N., Kato Y. Tanaka H., Shigenobu
K.: Differential effects of hypoxia on electrical and mechanical activities
of isolated ventricular muscles from fetal and adult guinea-pigs.
Gen. Pharmacol. 25:15-18 (1994) |
▲
1993
24) |
Tanaka H., Takagi N, Shigenobu
K.: Effects of ryanodine and calcium antagonists on embryonic and
hatched chick myocardium. J. Dev. Physiol. 19:235-240 (1993) |
23) |
Agata N., Tanaka H., Shigenobu
K.: Developmental changes in action potential properties of the guinea-pig
myocardium. Acta Physiol. Scand. 149:331-337 (1993) |
22) |
Agata N.,Tanaka H., Shigenobu K.:
Possible action of cyclopiazonic acid on myocardial sarcoplasmic reticulum:
inotropic effects on neonatal and adult rat heart. Br. J. Pharmacol.
108:571-572 (1993) |
21) |
Tanaka H., Takahashi S., Shigenobu
K.: Hypotensive effect of bopindolol in pithed rats. Gen. Pharmacol.
24:373-375 (1993) |
20) |
Tanaka H., Ikeda U, Shigenobu K.:
Positive chronotropic and inotropic effects of lysophosphatidylcholine
are mediated by norepinephrine released from sympathetic nerve terminals.
Gen. Pharmacol. 24:239-241 (1993) |
▲
1992
19) |
Agata N., Tanaka H., Shigenobu
K.: Effect of manganese on neonatal and adult rat heart: initial depression
and late augmentation of contractile force. Eur. J. Pharmacol. 222:223-226
(1992) |
18) |
Ikeya K., Saito K., Hayashi K.,Tanaka
H., Hagiwara Y., Yoshida M., Yamauchi A., Fukuyama Y., Ishiguro
T., Eguchi C., Ozawa E.: Molecular genetic and immunological analysis
of dystrophin of a young patient with X-linked muscular dystrophy.
Am. J. Med. Gen. 43:580-587 (1992) |
17) |
Saito K., Yoshida M., Tanaka H.:
Sensitivity of cultured and skinned chick myotube to calcium, strontium
and barium ions examined by recording isometric contractions. J. Cell.
Physiol. 150:45-51 (1992) |
▲
1991
16) |
Tanaka H., Hayashi K., Ozawa E.:
Positive immunostaining with dystrophin antibodies in mdx skeletal
muscle. Proc. Japan. Acad. 67B:148-152 (1991) |
15) |
Tanaka H., Ishiguro T., Eguchi
C., Saito K., Ozawa E.: Expression of a dystrophin-related protein
associated with the muscle cell membrane. Histochemistry 96:1-5 (1991) |
▲
1990
14) |
Tanaka H., Ozawa E.: Expression
of dystrophin mRNA and the protein in the developing rat heart. Biochem.
Biophys. Res. Comm. 172:824-829 (1990) |
13) |
Tanaka H., Ozawa E.: Developmental
expression of dystrophin on the rat myocardial cell membrane. Histochemistry
94:449-453 (1990) |
12) |
Tanaka H.,Ikeya K., Ozawa E.: Difference
in the expression pattern of dystrophin between the skeletal and cardiac
muscles of the mdx carrier mice. Histochemistry 93:447-452 (1990) |
11) |
Tanaka H., Shigenobu K.: Rat heart
organ culture for the study of trophic substances involved in the
maintenance of normal sensitivity to norepinephrine: possible involvement
of cAMP and search for other factors. Can. J. Physiol. Pharmacol.
68:898-902 (1990) |
10) |
Tanaka H., Shigenobu K.: Role of
b-adrenoceptor-adenylate cyclase system in the developmental decrease
in sensitivity to isoproterenol in fetal and neonatal rat heart. Br.
J. Pharmacol. 100:138-142 (1990) |
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原著論文 最新-2020|2019-2010|2009-2000|1999-1990|1989- |もとのページ|「心筋」トップ|ページ先頭
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