東邦大学へ メディアネットセンターへ バーチャルラボラトリへ  
バーチャルラボラトリ 心筋−心臓は電気とカルシウムイオンで動いている!−
東邦大学 薬学部薬物学教室  
田中 光 行方 衣由紀 M口正悟
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 心臓の病気と治療薬 | エホニジピン物語 | プロフィ−ル | 免責事項 |

田中 光 <たなか ひかる> 東邦大学薬学部教授、薬学博士

原著論文 最新-2010 | 2009-2000 | 1999-1990 | 1989- |
英文総説和文総説著書 |
学会発表 最新-2010 | 2009-2000 | 1999-1992 | 1991- |
特許 |
プロフィール |

原著論文 最新−2010年

2016
180) Hamaguchi S, Tsuneoka Y, Hikita K, Tanaka Y, Namekata I, Tanaka H. Enhancement of automaticity by mechanical stretch in the isolated guinea pig pulmonary vein myocardium. Biol. Pharm. Bull. in press
179) Nakamura Y, Sasaki R, Cao X, Wada T, Hamaguchi S, Izumi-Nakaseko H, Ando K, Tanaka H, Takahara A, Sugiyama A. Intravenous anti-influenza drug oseltamivir will not induce torsade depointes: Evidences from proarrhythmia model and action-potential assay. J. Pharmacol. Sci. in press.
2015
178) Hamaguchi S, Tsuneoka Y, Tanaka A, Irie M, Tsuruta M, Nakayama T, Namekata I, Nada M, Aimoto M, Takahara A, Tanaka H. Manifestation of automaticity in the pulmonary vein myocardium of rats with abdominal aorto-venocaval shunt. J. Pharmacol. Sci. 128:212-215 (2015)
177) Ikaga R, Namekata I, Kotiadis VN, Ogawa H, Duchen M, Tanaka H, Iida-Tanaka N. Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem. Biophys. Rep. 4:187-195 (2015)
176) Namekata I, Hamaguchi S, Tanaka H. Pharmacological discrimination of plasmalemmal and mitochondrial sodium-calcium exchanger in cardiomyocyte-derived H9c2 cells. Biol.Pharm. Bull. 38:147-150 (2015)
175) Hasegawa C, Ikaga R, Namekata I, Tanaka H, Iida-Tanaka N. The role of mitochondria on the formation of lipid droplets in adipocytes: Live cell imaging of mitochondria and lipid droplets. Int. J. Hum.Cult. Stud. 25:268-270 (2015)
2014
174) Hamaguchi S, Kaneko M, Hashimoto R, Tamura M, Namekata I, Tanaka H, Iida-Tanaka N. Analysis of cellular morphology by confocal microscopy and a membrane-intercalating fluorescent dye PKH67. Int. J. Hum.Cult. Stud. 2014 24:217-221
173) Tanaka H, Takahashi Y, Hamaguchi S, Iida-Tanaka N, Oka T, Nishio M, Ohtsuki A, Namekata I. Effect of terfenadine and pentamidine on the hERG channel and its intracellular trafficking: Combined analysis with automated voltage clamp and confocal microscopy. Biol. Pharm. Bull. 2014 37(11):1826-1830
172) Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari, H Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. J. Clin. Invest. 2014 124(6):2785-2801
2013
171) Hamaguchi S., Kawakami Y., Honda Y., Nemoto K., Ayaka S., Namekata I., Tanaka H. Developmental changes in excitation-contraction mechanisms of the mouse ventricular myocardium as revealed by functional and confocal imaging analyses. J. Pharmacol. Sci. 123:167-175 (2013)
170) Namekata I., Hamaguchi S., Wakasugi Y., Ohara M., Hirota Y., Tanaka H., Y. Ellagic acid and gingerol, activators of the sarco-endoplasmic reticulum Ca ATPase, ameliorate diabetes mellitus-induced diastolic dysfunction in isolated murine ventricular myocardia. Eur. J. Pharmacol. 706:48-55 (2013)
169) Kitahara K., Nakamura Y., Tsuneoka Y., Adachi-Akahane S., Tanaka H., Yamazaki H., Takahara A., Yamazaki J., Ikeda T., Sugiyama A. Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro. Cardiovas. Toxicol. 13:234-243 (2013)
168) Takahara A., Takeda K., Hagiwara M., Tanaka H. Electrophysiological effects of the antiarrhythmic drug bepridil on the guinea pig pulmonary vein myocardium. Biol. Pharm. Bull. 36:311-315 (2013)
167) Namekata I., Kaeriyama S., Ikaga R., Tanaka H., Iida-Tanaka N. Cellular flavoprotein fluorescence imaging for the analysis of mitochondrial function. Int. J. Hum. Cult. Stud. 23: 305-309 (2013)
2012
166) Takahara A., Fujiwara K., Ohtsuki A., Oka T., Namekata I., Tanaka H. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J. Pharmacol. Sci. 120:165-175 (2012)
165) Tsuneoka Y., Kobayashi Y., Honda Y., Namekata I., Tanaka H. Electrical activity of the mouse pulmonary vein myocardium. J. Pharmacol. Sci. 119:287-292 (2012)
164) Takahara A., Takeda K., Tsuneoka Y., Hagiwara M., Namekata I., Tanaka H. Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea pig pulmonary vein myocardium. J. Pharmacol. Sci. 118:506-511 (2012)
163) Asada Y., Li W., Terada T., Kuang X., Li Q., Takafumi Y., Hamaguchi S., Namekata I., Tanaka H., Koike K. Labdane-type diterpenoids from hairy root cultures of Coleus forskolii. Phytochemistry 79:141-146 (2012)
162) Yoshizawa A., Nagai S., Baba Y., Yamada T., Matsui M., Tanaka H., Miyoshi S., Amagai M., Yoshikawa T., Ogawa S., Koyosu S. Autoimmunity against M2 muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. Eur. J. Immunology 42:1152-1163 (2012)
2011
161) Nouchi H., Kiryu N., Kimata M., Tsuneoka Y., Hamaguchi S., Namekata I., Takahara A., Shigenobu K., Tanaka H. Developmental changes in action potential prolongation by K+-channel blockers in chick ventricle. J. Pharmacol. Sci. 115:235-238 (2011)
160) Takahara A, Sugimoto T, Kitamura T, Takeda K, Yayoi Tsuneoka, Namekata I, Tanaka H. Electrophysiological and pharmacological characteristics of triggered activity elicited in guinea-pig pulmonary vein myocardium. J. Pharmacol. Sci. 115:176-181 (2011)
159) Namekata I., Tsuruoka N., Tsuneoka Y., Matsuda T., Takahara A., Tanaka Y., Suzuki T., Takahashi T., Iida-Tanaka N., Tanaka H. Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. Biol. Pharm. Bull. 34: 153-155(2011)
2010
158) Namekata I., Tsuneoka Y., Akiba A., Nakamura H., Shimada H., Takahara A., Tanaka H. Intracellular calcium and membrane potential oscillations in the guinea-pig and rat pulmonary vein myocardium. Bioimages 18:11-22 (2010)
157) Yamashiro K., Sasano T., Tojo K., Namekata I., Kurokawa J., Sawada N., Suganami T., Kamei Y., Tanaka H., Tajima N., Utsunomiya K., Ogawa Y., Furukawa T. Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem Biophys Res Commun. 398:284-289 (2010)
156) Agata N., Kato Y., Namekata I., Takahara A., Tanaka H., Chino D., Koike K., Tanaka Y. H2 receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria. Biol. Pharm. Bull. 33:2033-2035 (2010)
155) Tanaka H., Namekata I., Ogawa T., Tsuneoka Y., Komikado C., Takahara A., Iida-Tanaka N., Izumi-Nakaseko H., Tsuru H., Adachi-Akahane S. Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits Cav1.2, Cav1.3 and Cav3.1. Eur J Pharmacol. 649:263-267 (2010)
154) Tanaka H., Namekata I., Hamaguchi S., Kawamura T., Masuda H., Tanaka Y., Iida-Tanaka N., Takahara A. Effect of NIP-142 on potassium channel α-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization. Biol. Pharm. Bull. 33: 138-141 (2010)

原著論文 最新-2010 | 2009-2000 | 1999-1990 | 1989- |
英文総説和文総説著書 |
学会発表 最新-2010 | 2009-2000 | 1999-1992 | 1991- |
特許 |
プロフィール |

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